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首页> 外文期刊>Journal of bacteriology >The Opportunistic Human Pathogen Acinetobacter baumannii Senses and Responds to Light
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The Opportunistic Human Pathogen Acinetobacter baumannii Senses and Responds to Light

机译：机会性人类病原鲍曼不动杆菌感知并响应光

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Light is a ubiquitous environmental signal that many organisms sense and respond to by modulating their physiological responses accordingly. While this is an expected response among phototrophic microorganisms, the ability of chemotrophic prokaryotes to sense and react to light has become a puzzling and novel issue in bacterial physiology, particularly among bacterial pathogens. In this work, we show that the opportunistic pathogen Acinetobacter baumannii senses and responds to blue light. Motility and formation of biofilms and pellicles were observed only when bacterial cells were incubated in darkness. In contrast, the killing of Candida albicans filaments was enhanced when they were cocultured with bacteria under light. These bacterial responses depend on the expression of the A. baumannii ATCC 17978 A1S_2225 gene, which codes for an 18.6-kDa protein that contains an N-terminal blue-light-sensing-using flavin (BLUF) domain and lacks a detectable output domain(s). Spectral analyses of the purified recombinant protein showed its ability to sense light by a red shift upon illumination. Therefore, the A1S_2225 gene, which is present in several members of the Acinetobacter genus, was named blue-light-sensing A (blsA). Interestingly, temperature plays a role in the ability of A. baumannii to sense and respond to light via the BlsA photoreceptor protein.
机译：光是一种普遍存在的环境信号，许多生物通过相应地调节其生理反应来感知和响应。尽管这是光养微生物中的预期反应，但化学营养原核生物对光的感应和反应能力已成为细菌生理学中一个令人费解且新颖的问题，尤其是在细菌病原体中。在这项工作中，我们表明机会性病原体鲍曼不动杆菌感知并响应蓝光。仅当细菌细胞在黑暗中孵育时，才能观察到运动性以及生物膜和防护膜的形成。相比之下，白色念珠菌细丝与细菌在光照下共培养时，其杀灭力增强。这些细菌反应取决于 A的表达。 baumannii ATCC 17978 A1S_2225基因，编码一个18.6-kDa的蛋白质，该蛋白质包含N端使用感蓝光的黄素（BLUF）域，但缺少可检测的输出域。纯化的重组蛋白的光谱分析表明其具有在照明时通过红移感测光的能力。因此，存在于不动杆菌属几个成员中的A1S_2225基因被命名为蓝光感应A（ blsA ）。有趣的是，温度在 A的能力中起作用。鲍曼氏菌通过BlsA感光蛋白感应并响应光。

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