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首页> 外文期刊>Journal of bacteriology >Cholesterol Is Not an Essential Source of Nutrition for Mycobacterium tuberculosis during Infection
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Cholesterol Is Not an Essential Source of Nutrition for Mycobacterium tuberculosis during Infection

机译:胆固醇不是感染过程中结核分枝杆菌的必需营养来源

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摘要

Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.
机译:结核分枝杆菌需要Rv1106c( hsd ;3β-羟基类固醇脱氢酶)作为胆固醇作为唯一碳源的生长,而Rv3409c不是。在受感染的巨噬细胞或豚鼠中,Rv1106c的突变不会降低结核分枝杆菌的生长。我们得出结论,在感染过程中不需要胆固醇作为营养来源。

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