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首页> 外文期刊>Journal of bacteriology >Altered Levels of Salmonella DNA Adenine Methylase Are Associated with Defects in Gene Expression, Motility, Flagellar Synthesis, and Bile Resistance in the Pathogenic Strain 14028 but Not in the Laboratory Strain LT2
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Altered Levels of Salmonella DNA Adenine Methylase Are Associated with Defects in Gene Expression, Motility, Flagellar Synthesis, and Bile Resistance in the Pathogenic Strain 14028 but Not in the Laboratory Strain LT2

机译：沙门氏菌DNA腺嘌呤甲基化酶水平的变化与致病菌株14028（而非实验室菌株LT2）的基因表达，运动性，鞭毛合成和胆汁抗性缺陷相关。

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Comparative genomic analysis has revealed limited strain diversity between Salmonella pathogenic and nonpathogenic isolates. Thus, some of the relative virulence and host-immune response disparities may be credited to differential gene regulation rather than gross differences in genomic content. Here we show that altered levels of Salmonella DNA adenine methylase (Dam) resulted in acute defects in virulence-associated gene expression, motility, flagellin synthesis, and bile resistance in the Salmonella pathogenic strain 14028 but not in avirulent laboratory strain LT2. The defects in motility exhibited by 14028 in response to altered Dam levels was not dependent on the presence of the regulatory protein, RpoS. The transitioning between flagellar types (phase variation) was also differentially regulated in 14028 versus LT2 in response to dam levels, resulting in distinct differences in flagellin expression states. These data suggest that differential gene regulation may contribute to the relative virulence disparities observed between Salmonella serovars that are closely related at the DNA level.
机译：比较基因组分析显示，沙门氏菌致病性和非致病性分离株之间的菌株多样性有限。因此，某些相对毒力和宿主-免疫反应的差异可能是由于基因调控差异，而不是基因组含量的总体差异造成的。在这里，我们显示改变的沙门氏菌 DNA腺嘌呤甲基化酶（Dam）水平导致毒力相关基因表达，运动性，鞭毛蛋白合成和沙门氏菌的胆汁抵抗力的急性缺陷致病性菌株14028，但无毒实验室菌株LT2除外。 14028响应于改变的水坝水平而表现出的运动性缺陷并不取决于调节蛋白RpoS的存在。鞭毛类型之间的过渡（相变）在14028和LT2中也受到 dam 水平的差异调节，导致鞭毛蛋白表达状态明显不同。这些数据表明差异基因调控可能导致在DNA水平上密切相关的沙门氏菌血清之间的相对毒力差异。

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