Molecular Basis of the Indole-Negative Reaction in Shigella Strains: Extensive Damages to the tna Operon by Insertion Sequences

Ferdousi Rezwan; Ruiting Lan; Peter R. Reeves

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Molecular Basis of the Indole-Negative Reaction in Shigella Strains: Extensive Damages to the tna Operon by Insertion Sequences

机译：志贺氏菌菌株中吲哚-阴性反应的分子基础：插入序列对tna操纵子的广泛损害。

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The molecular basis of the loss of tryptophan utilization (indole-negative phenotype) of Shigella strains, in effect clones of Escherichia coli, was investigated. Analysis of the tna operon of 23 Shigella strains representing each of the indole-negative serotypes revealed that insertion sequence-mediated insertion and/or deletions damaged the tna operon, leading to inability to convert tryptophan to indole. These events differ for cluster 1, cluster 3, and the outlier Shigella strains, confirming our previous observation of independent origins of these lineages from within E. coli. Parallel loss of the trait and prevalence of indole-negative strains suggest that the trait is deleterious in Shigella strains and advantages those without it.

机译：研究了大肠杆菌的有效克隆中志贺氏菌菌株色氨酸利用损失（吲哚阴性表型）的分子基础。对代表每种吲哚阴性血清型的23株志贺菌的 tna 操纵子进行分析后发现，插入序列介导的插入和/或缺失破坏了 tna 。 em>操纵子，导致无法将色氨酸转换为吲哚。这些事件对于聚类1，聚类3和异常的 Shigella 菌株有所不同，这证实了我们先前对 E内部这些谱系的独立起源的观察。大肠杆菌。吲哚阴性菌株的性状和流行率并行下降表明，该性状在志贺氏菌菌株中是有害的，而对没有该菌株的优势。 展开▼

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《Journal of bacteriology》 |2004年第21期|共6页

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Ferdousi Rezwan; Ruiting Lan; Peter R. Reeves;
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中图分类微生物学;

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1. The distribution of insertion sequences in the genome of Shigella flexneri strain 2457T [J] . Zaghloul L, Tang C, Chin HY, FEMS Microbiology Letters . 2007,第2期

机译：弗氏志贺氏菌2457T菌株基因组中插入序列的分布

2. Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences [J] . Giulia Pilla, Gareth McVicker, Christoph M. Tang PLoS Genetics . 2017,第9期

机译：志贺氏菌毒力质粒的遗传可塑性由插入序列之间的分子内和分子间事件介导

3. Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences [J] . Giulia Pilla, Gareth McVicker, Christoph M. Tang PLoS Genetics . 2017,第9期

机译：志贺氏菌毒力质粒的遗传可塑性由插入序列之间的分子内和分子间事件介导

4. Highly Efficient Synthesis of Oxindole Derivatives via Catalytic Intramolecular C-H Insertion Reactions of Diazoamides [C] . Nga Phan-Thi-Thanh, Masaya Tone, Hayato lnoue International Conference on Science and Technology . 2020

机译：通过催化分子内C-H插入式重氮酰胺的催化分子内C-H插入反应高效合成氧吲哚衍生物

5. Bacillus thuringiensis strain M15, a novel autoagglutinable, nonserotypeable strain-cloning and characterization of a novel cry31A-type crystal protein gene, cry31Aa2, and two new insertion sequences, IS231M and -N. [D] . Jung, Yong-Chul. 2002

机译：苏云金芽孢杆菌菌株M15，一种新型的可自动凝集，不可血清分型的菌株克隆，并鉴定了一种新型cry31A型晶体蛋白基因cry31Aa2以及两个新的插入序列IS231M和-N。

6. Molecular Basis of the Indole-Negative Reaction in Shigella Strains: Extensive Damages to the tna Operon by Insertion Sequences [O] . Ferdousi Rezwan, Ruiting Lan, Peter R. Reeves 2004

机译：志贺氏菌菌株中吲哚-阴性反应的分子基础：插入序列对tna操纵子的广泛损害。

7. Molecular Basis of the Indole-Negative Reaction in Shigella Strains: Extensive Damages to the tna Operon by Insertion Sequences [O] . Rezwan, Ferdousi, Lan, Ruiting, Reeves, Peter R. 2004

机译：志贺氏菌菌株中吲哚-阴性反应的分子基础：插入序列对tna操纵子的广泛损害。

8. Automated insertion of sequences into a ribosomal RNA alignment: An application of computational linguistics in molecular biology [R] . Taylor, R. C. 1991

机译：将序列自动插入核糖体RNa比对：计算语言学在分子生物学中的应用

1. 宋内氏志贺氏菌I相抗原在 E.coli HB101 菌株中的表达 [J] . 牟兆钦 . 遗传 . 1986,第002期

1. An oligonucleotide primer, a polymerase chain reaction-based method for the amplification of virulent shigella species and entero-invasive escherichia coli strain nucleic acid; a diagnostic test for the detection of virulent shigella species and entero-invasive escherichia coli strains in a sample and a kit for use in the test. [P] . 外国专利： ZA200001348B . 2000-10-20

机译：寡核苷酸引物，一种基于聚合酶链反应的方法，用于扩增有毒志贺氏菌和肠侵袭性大肠杆菌菌株核酸;用于检测样品中强毒志贺氏菌和肠侵袭性大肠杆菌菌株的诊断测试，以及用于该测试的试剂盒。

2. Methods for identifying species or Shigella and E. coli using operon sequence analysis [P] . 外国专利： US6727061B2 . 2004-04-27

机译：使用操纵子序列分析鉴定物种或志贺氏菌和大肠杆菌的方法

3. METHODS FOR IDENTIFYING SPECIES OR SHIGELLA AND E. COLI USING OPERON SEQUENCE ANALYSIS [P] . 外国专利： US2003087227A1 . 2003-05-08

机译：利用操纵子序列分析鉴定物种或志贺菌和大肠杆菌的方法

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Molecular Basis of the Indole-Negative Reaction in Shigella Strains: Extensive Damages to the tna Operon by Insertion Sequences

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