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首页> 外文期刊>Journal of bacteriology >Complete Genome Sequence of Haemophilus somnus (Histophilus somni) Strain 129Pt and Comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd
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Complete Genome Sequence of Haemophilus somnus (Histophilus somni) Strain 129Pt and Comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd

机译：嗜血嗜血杆菌（Histophilus somni）129Pt菌株的完整基因组序列以及与杜克雷嗜血杆菌35000HP和流感嗜血杆菌Rd的比较

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摘要

Haemophilus somnus can be either a commensal of bovine mucosal surfaces or an opportunistic pathogen. Pathogenic strains of H. somnus are a significant cause of systemic disease in cattle. We report the genome sequence of H. somnus 129Pt, a nonpathogenic commensal preputial isolate, and the results of a genome-wide comparative analysis of H. somnus 129Pt, Haemophilus influenzae Rd, and Haemophilus ducreyi 35000HP. We found unique genes in H. somnus 129Pt involved in lipooligosaccharide biosynthesis, carbohydrate uptake and metabolism, cation transport, amino acid metabolism, ubiquinone and menaquinone biosynthesis, cell surface adhesion, biosynthesis of cofactors, energy metabolism, and electron transport. There were also many genes in common among the three organisms. Our comparative analyses of H. somnus 129Pt, H. influenzae Rd, and H. ducreyi 35000HP revealed similarities and differences in the numbers and compositions of genes involved in metabolism, host colonization, and persistence. These results lay a foundation for research on the host specificities and niche preferences of these organisms. Future comparisons between H. somnus 129Pt and virulent strains will aid in the development of protective strategies and vaccines to protect cattle against H. somnus disease.
机译：嗜血嗜血杆菌可以是牛粘膜表面的共性，也可以是机会性病原体。 H的致病菌株。咽痛是牛全身性疾病的重要原因。我们报告了 H的基因组序列。 129Pt，一种非致病性的共产副产物，以及 H的全基因组比较分析的结果。 somnus 129Pt，流感嗜血杆菌 Rd和 ducreyi嗜血杆菌 35000HP。我们在 H中发现了独特的基因。 somnus 129Pt参与脂寡糖的生物合成，碳水化合物的吸收和代谢，阳离子转运，氨基酸代谢，泛醌和甲萘醌的生物合成，细胞表面粘附，辅因子的生物合成，能量代谢和电子转运。三种生物之间也有许多共同的基因。我们对 H的比较分析。 somnus 129Pt， H。流感 Rd和 H。 ducreyi 35000HP揭示了与代谢，宿主定植和持久性有关的基因的数量和组成的相似性和差异。这些结果为研究这些生物的宿主特异性和生态位偏好奠定了基础。 H之间的未来比较。 somnus 129Pt和强毒株将有助于开发保护策略和疫苗，以保护牛免受 H侵害。昏睡病。

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