Draft Genome Sequence of Streptomyces globisporus C-1027, Which Produces an Antitumor Antibiotic Consisting of a Nine-Membered Enediyne with a Chromoprotein

Lifei Wang; Songmei Wang; Qing He; Tengfei Yu; Qinglian Li; Bin Hong

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Draft Genome Sequence of Streptomyces globisporus C-1027, Which Produces an Antitumor Antibiotic Consisting of a Nine-Membered Enediyne with a Chromoprotein

机译：拟南芥链霉菌C-1027的基因组序列草案，可产生由九元烯丙二酸和一种色蛋白组成的抗肿瘤抗生素。

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Streptomyces globisporus C-1027 is the producer of antitumor antibiotic C-1027, a nine-membered enediyne-containing compound. Here we present a draft genome sequence of S. globisporus C-1027 containing the intact biosynthetic gene cluster for this antibiotic. The genome also carries numerous sets of genes for the biosynthesis of diverse secondary metabolites.

机译：globisporus C-1027链霉菌是抗肿瘤抗生素C-1027（一种含九元烯二炔的化合物）的生产商。在这里，我们提出了一种含完整抗生素生物合成基因簇的球孢链球菌C-1027基因组序列草案。该基因组还携带了许多基因，用于多种次生代谢产物的生物合成。

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《Journal of bacteriology》 |2012年第15期|共1页
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Lifei Wang; Songmei Wang; Qing He; Tengfei Yu; Qinglian Li; Bin Hong;
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中图分类微生物学;
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1. Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production [J] . Murrell JM, Liu W, Shen B Journal of natural products . 2004,第2期

机译：烯二炔抗肿瘤抗生素C-1027生物合成途径中SgcA1α-D-吡喃葡萄糖基-1-磷酸胸苷基转移酶的生化特性和sglocA1在球孢链霉菌中的过表达以改善C-1027的产生
2. Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production [J] . Murrell JM, Liu W, Shen B Journal of natural products . 2004,第2期

机译：烯二炔抗肿瘤抗生素C-1027生物合成途径中SgcA1α-D-吡喃葡萄糖基-1-磷酸胸苷基转移酶的生化特性和sglocA1在球孢链霉菌中的过表达以改善C-1027的产生
3. Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein. [J] . Liu W, Shen B Antimicrobial agents and chemotherapy. . 2000,第2期

机译：球形双链霉菌中烯二炔抗肿瘤抗生素C-1027的生产基因与编码C-1027载脂蛋白的cagA基因聚集在一起。
4. Towards Photoswitchable Enediyne Antitumor Antibiotics: Design, Synthesis, Photochemistry and Cycloaromatization of Prototype Enediynes [C] . A. Poloukhtine, D. Pandithavidana, G. Karpov European Symposium on Organic Chemistry . 2009

机译：朝向光学性enediyne抗肿瘤抗生素：原型Enediynes的设计，合成，光化学和聚环化
5. Genetic and biochemical characterization of C-1027 enediyne biosynthesis cluster from Streptomyces globisporus. [D] . Christenson, Steven Dale. 2003

机译：球孢链霉菌C-1027烯二炔生物合成簇的遗传和生化特征。
6. Draft Genome Sequence of Streptomyces globisporus C-1027 Which Produces an Antitumor Antibiotic Consisting of a Nine-Membered Enediyne with a Chromoprotein [O] . Lifei Wang, Songmei Wang, Qing He, 2012

机译：拟南芥链霉菌C-1027的基因组序列草案可产生由九元烯丙二酸和一种色蛋白组成的抗肿瘤抗生素。
7. Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein [O] . Liu, Wen, Shen, Ben 2000

机译：球双链霉菌中产生Enediyne抗肿瘤抗生素C-1027的基因与编码C-1027载脂蛋白的cagA基因聚集在一起

Draft Genome Sequence of Streptomyces globisporus C-1027, Which Produces an Antitumor Antibiotic Consisting of a Nine-Membered Enediyne with a Chromoprotein

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