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首页> 外文期刊>Journal of bacteriology >Diversity of Prophages in Dominant Staphylococcus aureus Clonal Lineages
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Diversity of Prophages in Dominant Staphylococcus aureus Clonal Lineages

机译：优势金黄色葡萄球菌克隆谱系中的噬菌体多样性。

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Temperate bacteriophages play an important role in the pathogenicity of Staphylococcus aureus, for instance, by mediating the horizontal gene transfer of virulence factors. Here we established a classification scheme for staphylococcal prophages of the major Siphoviridae family based on integrase gene polymorphism. Seventy-one published genome sequences of staphylococcal phages were clustered into distinct integrase groups which were related to the chromosomal integration site and to the encoded virulence gene content. Analysis of three marker modules (lysogeny, tail, and lysis) for phage functional units revealed that these phages exhibit different degrees of genome mosaicism. The prevalence of prophages in a representative S. aureus strain collection consisting of 386 isolates of diverse origin was determined. By linking the phage content to dominant S. aureus clonal complexes we could show that the distribution of bacteriophages varied remarkably between lineages, indicating restriction-based barriers. A comparison of colonizing and invasive S. aureus strain populations revealed that hlb-converting phages were significantly more frequent in colonizing strains.
机译：温和的噬菌体在金黄色葡萄球菌的致病性中起重要作用，例如通过介导毒力因子的水平基因转移。在这里，我们建立了一个基于整合酶基因多态性的主要 Siphoviridae 家族葡萄球菌噬菌体分类方案。公布的葡萄球菌噬菌体的71个基因组序列被分为不同的整合酶组，这些整合酶组与染色体整合位点和编码的毒力基因含量有关。对噬菌体功能单元的三个标记模块（溶源性，尾巴和裂解）的分析表明，这些噬菌体表现出不同程度的基因组镶嵌。在典型的 S中，预言的普遍性。确定了由386种不同来源的分离物组成的金黄色葡萄球菌菌株。通过将噬菌体含量与显性 S相关联。金黄色葡萄球菌的克隆复合体可以证明噬菌体的分布在谱系之间​​有显着变化，表明基于限制的屏障。殖民化和侵袭性 S的比较。金黄色葡萄球菌种群表明， hlb 转化噬菌体在定殖菌株中的频率明显更高。

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