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首页> 外文期刊>Journal of bacteriology >The Biocide Chlorine Dioxide Stimulates Biofilm Formation in Bacillus subtilis by Activation of the Histidine Kinase KinC
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The Biocide Chlorine Dioxide Stimulates Biofilm Formation in Bacillus subtilis by Activation of the Histidine Kinase KinC

机译：杀菌剂二氧化氯通过组氨酸激酶KinC的激活刺激枯草芽孢杆菌中的生物膜形成。

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Bacillus subtilis forms biofilms in response to signals that remain poorly defined. We report that biofilm formation is stimulated by sublethal doses of chlorine dioxide (ClO2), an extremely effective and fast-acting biocide. ClO2 accelerated biofilm formation in B. subtilis as well as in other bacteria, suggesting that biofilm formation is a widely conserved response to sublethal doses of the agent. Biofilm formation depends on the synthesis of an extracellular matrix that holds the constituent cells together. We show that the transcription of the major operons responsible for the matrix production in B. subtilis, epsA-epsO and yqxM-sipW-tasA, was enhanced by ClO2, in a manner that depended on the membrane-bound kinase KinC. Activation of KinC appeared to be due to the ability of ClO2 to collapse the membrane potential. Importantly, strains unable to make a matrix were hypersensitive to ClO2, indicating that biofilm formation is a defensive response that helps protect cells from the toxic effects of the biocide.
机译：枯草芽孢杆菌会形成生物膜，以响应仍不清楚的信号。我们报告说，亚致死剂量的二氧化氯（ClO 2 ）可以刺激生物膜的形成，二氧化氯是一种非常有效且作用迅速的杀菌剂。 ClO 2 促进了 B中生物膜的形成。枯草杆菌以及其他细菌，表明生物膜的形成是对亚致死剂量药剂的广泛保守的反应。生物膜的形成取决于将组成细胞保持在一起的细胞外基质的合成。我们表明负责 B中的基质生产的主要操纵子的转录。枯草， epsA-epsO 和 yqxM-sipW-tasA 由ClO 2 增强，其依赖于膜结合激酶KinC。 KinC的激活似乎是由于ClO 2 破坏膜电位的能力所致。重要的是，无法制成基质的菌株对ClO 2 高度敏感，表明生物膜的形成是一种防御反应，有助于保护细胞免受杀生物剂的毒性作用。

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