...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Scientific reports. >Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis
【24h】

Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis

机译：白细胞介素6基因多态性与中国汉族风湿性关节炎的关联：病例对照研究和荟萃分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to investigate the possible association in the interleukin-6 (IL-6) gene with Rheumatoid arthritis (RA) in Chinese Han population from Shandong Province. Target regions of IL-6 gene were amplified by polymerase chain reaction (PCR) and genotyped. A logistic regression analysis was performed to detect potential associations in our case-control sample, the odd ratio(OR) and 95% confidence intervals(CIs) were calculated. Furthermore, we systematically tracked all the published studies in the field and performed a meta-analysis for the single nucleotide polymorphisms (SNPs) under study. 256 RA patients and 331 healthy controls were recruited into the case-control study. We found allele frequencies of rs1800795, rs1800797 and rs1474347 in RA patients differ from control subjects (P = 0.016, 0.024, 0.020, respectively). Significant difference was observed in haplotype frequencies of GCCGCT between RA patients and controls (P = 0.0001, OR = 4.066, 95%CI = 1.891 ~ 8.746), while GGCGCT frequencies was found lower in RA than controls (P = 0.006, OR = 0.669, 95%CI = 0.501 ~ 0.894). The results of the meta-analysis showed association polymorphism within the IL-6 promoter with RA. These findings suggest that rare IL-6 gene polymorphisms may associate with RA susceptibility in Han Chinese populations; however further studies are needed to assess the validity of the association of IL-6 with RA.
机译：这项研究的目的是调查山东省中国汉族人群中白介素6（IL-6）基因与类风湿关节炎（RA）的可能联系。通过聚合酶链反应（PCR）扩增IL-6基因的靶区域并进行基因分型。进行逻辑回归分析以检测病例对照样本中的潜在关联，计算出奇数比（OR）和95％置信区间（CIs）。此外，我们系统地跟踪了该领域中所有已发表的研究，并对正在研究的单核苷酸多态性（SNP）进行了荟萃分析。将256名RA患者和331名健康对照者纳入病例对照研究。我们发现RA患者中rs1800795，rs1800797和rs1474347的等位基因频率与对照组不同（分别为P = 0.016、0.024、0.020）。 RA患者和对照组之间GCCGCT的单倍型频率存在显着差异（P = 0.0001，OR = 4.066，95％CI = 1.891〜8.746），而RA中GGCGCT频率低于对照组（P = 0.006，OR = 0.669） ，95％CI = 0.501〜0.894）。荟萃分析的结果显示IL-6启动子内的多态性与RA相关。这些发现表明，汉族人群中罕见的IL-6基因多态性可能与RA易感性有关。然而，需要进一步的研究来评估IL-6与RA的关联的有效性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号