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首页> 外文期刊>Scientific reports. >Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis
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Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis

机译：体重指数对急性髓细胞性白血病和急性早幼粒细胞性白血病的发生和预后的影响：荟萃分析

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Previous studies have demonstrated an association between high body mass index (BMI) and acute myeloid leukemias (AML), particularly acute promyelocytic leukemia (APL). However, the effect of obesity and overweight on the incidence of AML is not supported by all studies, and the relationship between obesity and prognosis of AML and APL has not been established. Thus, we conducted a meta-analysis to determine the role of BMI on the risk and clinical outcome of AML, including APL. Twenty-six eligible studies enrolling 12,971 AML (including 866 APL) patients were retrieved and analyzed. Overweight and obesity was associated with an increased incidence of AML (relative risk [RR], 1.23; 95% confidence interval [CI], 1.12–1.35; P??0.001). High BMI did not significantly affect overall survival (OS) (hazard ratio [HR], 0.97; 95% CI, 0.92–1.03; P?=?0.323) or disease-free survival (HR, 0.98; 95% CI, 0.88–1.10; P?=?0.755) in patients with non-APL AML. By contrast, APL patients with high BMI had shorter OS (HR, 1.77; 95% CI, 1.26–2.48; P?=?0.001) and a higher risk of differentiation syndrome (HR, 1.53; 95% CI, 1.03–2.27, P?=?0.04). Overall, our findings suggest that patients with overweight or obesity have a higher incidence of AML, and high BMI is a predictor of adverse clinical outcomes in APL.
机译：先前的研究表明，高体重指数（BMI）与急性髓细胞性白血病（AML），尤其是急性早幼粒细胞性白血病（APL）之间存在关联。但是，并非所有研究都支持肥胖和超重对AML发生的影响，并且肥胖与AML和APL预后之间的关系尚未建立。因此，我们进行了荟萃分析，以确定BMI对包括APL在内的AML风险和临床结果的作用。检索并分析了26项纳入研究的12971名AML（包括866名APL）患者。超重和肥胖与AML的发生率增加相关（相对风险[RR]为1.23; 95％置信区间[CI]为1.12-1.35; P <0.001）。高BMI不会显着影响总生存（OS）（危险比[HR]为0.97; 95％CI为0.92-1.03; P <=？0.323）或无病生存率（HR为0.98; 95％CI为0.88–非APL AML患者为1.10; P？=？0.755）。相比之下，高BMI的APL患者的OS较短（HR为1.77; 95％CI为1.26–2.48; P <= 0.001），分化综合征的风险较高（HR为1.53; 95％CI为1.03–2.27， P≥0.04）。总体而言，我们的研究结果表明，超重或肥胖患者的AML发生率较高，而BMI较高是APL不良临床预后的指标。

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