...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of genetics >Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration
【24h】

Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration

机译：ERK1 / 2信号通路的八条路径调节大鼠肝再生中的肝细胞增殖

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although it is known that hormones, growth factors and integrin promote hepatocyte proliferation in liver regeneration (LR) through ERK1/2 signalling pathway, reports about regulating processes of its intracellular paths in hepatocytes of LR are limited. This study aims at exploring which paths of ERK1/2 signalling pathway participate in the regulation of rat LR, especially in hepatocyte proliferation, and how they do so. In all, 14 paths and 165 genes are known to be involved in ERK1/2 signalling pathway. Of them, 161 genes are included in Rat Genome 230 2.0 Array. This array was used to detect expression changes of genes related to ERK1/2 signalling pathway in isolated hepatocytes of rat LR, showing that 60 genes were related to hepatocytes of LR. In addition, bioinformatics and systems biology methods were used to analyse the roles of 14 above paths in regenerating hepatocytes. We found that three paths, RTK a?’ SHC a?’ GRB2/SOS a?’ RAS a?’ RAF, Integrin e??? a?’ FAK a?’ RAC a?’ PAK a?’ RAF and G e??? e??? a?’ PI3K e??? e??? a?’ RAC a?’ PAK a?’ RAF, promoted the G1 phase progression of hepatocytes by activating ERK1/2. A further four paths, Gq a?’ PLC e??? a?’ PKC a?’ SRC/PYK2 a?’ GRB2/SOS a?’ RAS a?’ RAF, RTK a?’ PLC e??? a?’ PKC a?’ SRC/PYK2 a?’ GRB2/SOS a?’ RAS a?’ RAF, Integrin e??? a?’ FAK/SRC a?’ GRB2/SOS a?’ RAS a?’ RAF and Integrin e???a?’ FAK a?’ RAC a?’ PAK a?’ RAF, advanced the cell progression of S phase and G2/M checkpoint by activating ERK1/2, and so did PP1/2 a?’ Mek1/2 by decreasing the negative influence on ERK1/2. At the late phase of LR, Ge???s a?’ AC a?’ EPAC a?’ Rap1 a?’ Raf blocked hepatocyte proliferation by decreasing the activity of ERK1/2 and so did PP1/2 a?’ Mek1/2. In summary, 60 genes and 8 paths of ERK1/2 signalling pathway regulated hepatocyte proliferation in rat LR.
机译：虽然已知激素，生长因子和整联蛋白通过ERK1 / 2信号通路促进肝再生（LR）中的肝细胞增殖，但报告了关于其肝细胞的细胞内径的调节过程的限制。本研究旨在探索ERK1 / 2信号通路的哪些路径参与大鼠LR的调节，特别是在肝细胞增殖中，以及它们的方式。在所有情况下，已知14个路径和165个基因参与ERK1 / 2信号通路。其中，161个基因包含在大鼠基因组230 2.0阵列中。该阵列用于检测与大鼠LR分离的肝细胞中ERK1 / 2信号通路相关的基因的表达变化，显示60个基因与LR的肝细胞有关。此外，生物信息学和系统生物学方法用于分析在再生肝细胞中上述14的作用。我们发现三条路径，rtk a？'shc a吗？'grb2 / sos a？'ras a？'raf，整合蛋糕e ??? a？''fak a？'rac a？'pak a？'raf和g e ??? e ??? a？''pi3k e ??? e ??? a？'Rac a？'pak a？'raf，通过激活ERK1 / 2促进肝细胞的G1相进展。另外四条路径，gq a？'plc e ??? a？'pkc a？'src / pyk2 a？'grb2 / sos a？'ras a？'raf，rtk a？'plc e ??? a？'pkc a？'src / pyk2 a？'grb2 / sos a？'ras a？'raf，整合在e ??? a？'fak / src a？'grb2 / sos a？'ras a？'raf和整合蛋白e ??? a？'fak a？'rac a？'pak a？'raf，提出了S阶段的细胞进展通过激活ERK1 / 2，通过降低ERK1 / 2的负面影响，通过激活ERK1 / 2来进行ERK1 / 2的G2 / M检查点，因此PP1 / 2A？'MEK1 / 2。在LR的后期阶段，Ge ??? sa？'eac a？'epac a？'Rap1 a吗？'Raf通过降低ERK1 / 2的活动来阻止肝细胞增殖，也是PP1 / 2 A？'MEK1 / 2 。总之，60个基因和8个ERK1 / 2信号传导途径的路径调节大鼠LR中的肝细胞增殖。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号