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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
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Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options

机译：念珠菌种类：目前流行病学，致病性，生物膜形成，天然抗真菌产品和新的治疗选择

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摘要

The incidence of fungal infections has increased significantly, so contributing to morbidity and mortality. This is caused by an increase in antimicrobial resistance and the restricted number of antifungal drugs, which retain many side effects. Candida species are major human fungal pathogens that cause both mucosal and deep tissue infections. Recent evidence suggests that the majority of infections produced by this pathogen are associated with biofilm growth. Biofilms are biological communities with a high degree of organization, in which micro-organisms form structured, coordinated and functional communities. These biological communities are embedded in a self-created extracellular matrix. Biofilm production is also associated with a high level of antimicrobial resistance of the associated organisms. The ability of Candida species to form drug-resistant biofilms is an important factor in their contribution to human disease. The study of plants as an alternative to other forms of drug discovery has attracted great attention because, according to the World Health Organization, these would be the best sources for obtaining a wide variety of drugs and could benefit a large population. Furthermore, silver nanoparticles, antibodies and photodynamic inactivation have also been used with good results. This article presents a brief review of the literature regarding the epidemiology of Candida species, as well as their pathogenicity and ability to form biofilms, the antifungal activity of natural products and other therapeutic options.
机译：真菌感染的发病率显着增加，因此有助于发病率和死亡率。这是由抗微生物抗性和限制抗真菌药物的增加引起的，其保留许多副作用。念珠菌种类是主要的人类真菌病原体，导致粘膜和深层组织感染。最近的证据表明，该病原体产生的大多数感染与生物膜生长有关。生物膜是具有高度组织的生物群群，其中微生物形式形成结构化，协调和功能性的社区。这些生物群群嵌入自创造成的细胞外基质中。生物膜生产也与相关生物的高水平抗微生物抗性相关。念珠菌物种形成耐药生物膜的能力是对人类疾病贡献的重要因素。植物作为其他形式的药物发现的替代研究引起了极大的关注，因为根据世界卫生组织的说法，这些是获得各种毒品的最佳来源，可以使大量人口受益。此外，银纳米粒子，抗体和光动力灭活也已与良好的结果一起使用。本文介绍了关于念珠菌物种流行病学的文献，以及它们致病性和形成生物膜的能力，天然产物的抗真菌活性和其他治疗选择。

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