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首页> 外文期刊>Infection and immunity >The major outer membrane protein of a single Chlamydia trachomatis serovar can possess more than one serovar-specific epitope.
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The major outer membrane protein of a single Chlamydia trachomatis serovar can possess more than one serovar-specific epitope.

机译：单个衣原体碎石瘤的主要外膜蛋白可具有多于一种特异性血清血清特异性表位。

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The major outer membrane proteins (MOMPs) of human Chlamydia trachomatis serovars exhibit four regions of variable amino acid sequences (VS1 to VS4) harboring serovar-specific B-cell epitopes. Antibody responses to these epitopes may contribute to acquired protection against human chlamydial infection. MOMP B-cell epitopes defined by 22 different serovar-specific or bispecific murine monoclonal antibodies were localized with synthetic peptides representing the four VS regions of seven genital serovars (D, Da, E, F, G, H, and K). Serovar F possessed two distinct serovar-specific epitopes, located in VS2 and VS4, while serovar K possessed three distinct serovar-specific epitopes, located in VS1, VS2, and VS4. Serovar D- and serovar Da-specific epitopes were located in VS1. Regardless of whether the serovar was from the B (serovars D, Da, and E), C (serovars H and K), or F-G (serovars F and G) serogroup, all serovar-specific epitopes were found in three discrete subgroups of MOMPs. These subregions comprised all central portion of VS1, residues 70 to 77; the amino-terminal half of VS2, residues 139 to 149; and the carboxyl-terminal third of VS4, residues 305 to 315. Monoclonal antibodies to each of these subregions neutralized infectivity in standard HaK cell culture assays. These findings are relevant to the development of an MOMP or MOMP subunit vaccine.
机译：人衣原体的主要外膜蛋白（MOMPS）的人衣原体甲瘤血清素塞洛瓦斯将四个区域的可变氨基酸序列（VS1至VS4）含有血清特异性B细胞表位。对这些表位的抗体反应可能有助于获得对人衣原体感染的保护。 MOMP B细胞表位由22种不同的Serovar特异性或双特异性鼠单克隆抗体定位，其是表示七种生殖器纱拉纱（D，DA，E，F，G，H和K）的四个VS区域的合成肽。 Serovar F拥有位于VS2和VS4中的两个不同的血清血清表位，而Serovar K具有位于VS1，VS2和VS4中的三种不同的血清基特异性表位。 Serovar D-和Serovar DA特异性表位位于VS1中。无论Serovar是否来自B（Serovars D，Da和E），C（血清瓦斯H和K），或FG（Serovars F和G）血清组，在MOMP的三个离散子组中发现了所有血清特异性表位。这些子区域包括VS1的所有中心部分，残留物70至77;氨基末端的一半VS2，残留物139至149;和Vs4的羧基 - 末端第三，残留物305至315.单克隆抗体对这些亚区中的每一个中和标准Hak细胞培养测定中的感染性。这些发现与MOMP或MOMP亚基疫苗的开发有关。

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