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首页> 外文期刊>Infection and immunity >Gastric invasion by Trypanosoma cruzi and induction of protective mucosal immune responses.
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Gastric invasion by Trypanosoma cruzi and induction of protective mucosal immune responses.

机译：胰腺癌Cruzi胃侵袭和保护性粘膜免疫反应的诱导。

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Trypanosoma cruzi is an intracellular parasite transmitted from a reduviid insect vector to humans by exposure of mucosal surfaces to infected insect excreta. We have used an oral challenge murine model that mimics vector-borne transmission to study T. cruzi mucosal infection. Although gastric secretions have microbicidal activity against most infectious pathogens, we demonstrate that T. cruzi can invade and replicate in the gastric mucosal epithelium. In addition, gastric mucosal invasion appears to be the unique portal of entry for systemic T. cruzi infection after oral challenge. The mucosal immune responses stimulated by T. cruzi gastric infection are protective against a secondary mucosal parasite challenge. This protective mucosal immunity is associated with increased numbers of lymphocytes that secrete parasite-specific immunoglobulin A. Our results document the first example of systemic microbial invasion through gastric mucosa and suggest the feasibility of a mucosal vaccine designed to prevent infection with this important human pathogen.
机译：胰蛋白酶瘤Cruzi是一种从Reduviid昆虫载体传播的细胞内寄生虫通过暴露于感染昆虫物虫的粘膜表面而来。我们使用了一个口腔挑战鼠模型，以模仿矢量传输以研究T.Cruzi粘膜感染。虽然胃分泌物具有针对最感染性病原体的杀微生物活性，但我们证明了T.Cruzi可以在胃粘膜上皮内侵入和复制。此外，胃黏膜侵袭似乎是口腔挑战后系统性T.Cruzi感染的独特门户。由T.Cruzi胃感染刺激的粘膜免疫反应对二次粘液寄生虫攻击进行保护。这种保护粘膜免疫与分泌寄生虫特异性免疫球蛋白A的淋巴细胞数增加有关。我们的结果通过胃粘膜制定了全身微生物侵袭的第一个例子，并提出了粘膜疫苗的可行性，设计用于预防这种重要人类病原体的感染。

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