Functional analysis of pneumolysin by use of monoclonal antibodies.

J R de los Toyos; F J Méndez; J F Aparicio; F Vázquez; M Del Mar García Suárez; A Fleites; C Hardisson; P J Morgan; P W Andrew; T J Mitchell

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Functional analysis of pneumolysin by use of monoclonal antibodies.

机译：用单克隆抗体的肺膜蛋白的功能分析。

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We have produced a panel of monoclonal antibodies to pneumolysin, the membrane-damaging toxin from Streptococcus pneumoniae. We have used these antibodies to identify three regions of the toxin sequence that are involved in the lytic mechanism of this toxin. Two of these sites probably form the cell binding site of this toxin. Antibodies to the third site inhibit the lytic action of this toxin but not the binding of this toxin to cells. This site is engaged in the oligomerization process involved in the formation of pores in cell membranes. Two of these epitopes are also present in the related toxin perfringolysin O.

机译：我们已经生产了一种单克隆抗体面板，对肺炎蛋白肺炎骨膜肺炎骨膜损伤的膜损伤。我们使用这些抗体来鉴定涉及该毒素的裂解机制的毒素序列的三个区域。这些位点中的两个可能形成该毒素的细胞结合位点。第三位点的抗体抑制该毒素的裂解作用，但不是该毒素与细胞的结合。该网站从事涉及细胞膜中孔的寡聚化过程。这些表位中的两种也存在于相关的Toxin灌注酚O.中存在。

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《Infection and immunity》 |1996年第2期|共5页
作者
J R de los Toyos; F J Méndez; J F Aparicio; F Vázquez; M Del Mar García Suárez; A Fleites; C Hardisson; P J Morgan; P W Andrew; T J Mitchell;
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中图分类医学免疫学;
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Functional analysis of pneumolysin by use of monoclonal antibodies.

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