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Effects of Carbon Dust Inhalation on the Cell-Mediated Immune Response in Mice

机译：碳粉吸入对小鼠细胞介导的免疫应答的影响

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The effects of carbon dust inhalation on the bone marrow-derived (B) and thymus-derived (T) lymphocyte populations of spleen and mediastinal lymph node (MLN) cultures were examined. The concanavalin A (Con A)-responsive cell population (T cells) in the spleen was found to be depressed after 7 days of pre-exposure to carbon dust. However, this effect was transient, and after 14, 21, and 28 days of pre-exposure to carbon dust, the Con A-responsive cells exhibited a 30 to 40% enhancement over control group responses. Conversely, Con A-responsive cells in the pooled MLN cultures exhibited depression, ranging from 22 to 33% below control group values, after 7, 14, and 28 days of pre-exposure to carbon dust. The lipopolysaccharide (LPS)-responsive cell population (B cells) in the spleens of carbon-exposed mice was found not to differ significantly from control group values after all times of pre-exposure. LPS-responsive cells in the MLN cultures exhibited enhancement, ranging from 49 to 74% above control values, after 14, 21, and 28 days of pre-exposure to carbon dust. The ability of carbon spleen cell cultures from carbon-exposed mice to undergo antigen induced blast transformation after sensitization with Mycobacterium tuberculosis H37Ra was also determined. Mice exposed to carbon dust inhalation 2 weeks before and 3 weeks after aerosol or subcutaneous immunization exhibited significantly enhanced ratios of transformation upon culture of their spleen lymphocytes with purified protein derivative of tuberculin.
机译：研究了碳粉吸入对脾脏衍生（B）和胸腺衍生（T）脾脏和纵容淋巴结（MLN）培养物的淋巴细胞群体的影响。在7天预接触碳粉尘后，发现脾脏中的康丹林A（CON A） - 夸张的细胞群（T细胞）被抑制。然而，这种效果是短暂的，并且在接触碳粉尘的14,21和28天后，CON响应细胞在对照组反应上表现出30％至40％的增强。相反，汇集的MLN培养物中的CON响应细胞表现出抑郁症，其低于对照组值低于22-33％，在7,14和28天后暴露于碳粉尘。发现碳暴露小鼠脾脏中的脂多糖（LPS） - 夸张的细胞群（B细胞）未在所有次曝光前从对照组值显着不同。在MLN培养物中的LPS响应细胞表现出增强，在14,21,21,21天后的49％至74％至74％至74％至74％至28天和的碳粉尘中。还测定了碳脾细胞从碳暴露小鼠中经历抗原诱导的抗原诱导的抗原转化的能力，并确定了分枝杆菌分枝杆菌分枝杆菌和H37Ra的敏化。在气溶胶或皮下免疫接种后2周和3周暴露于碳粉尘的小鼠表现出在脾脏淋巴细胞培养比结核蛋白的纯化蛋白质衍生物上显着增强了转化比例。

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