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首页> 外文期刊>Scientific reports. >Probiotics into outer space: feasibility assessments of encapsulated freeze-dried probiotics during 1 month’s storage on the International Space Station
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Probiotics into outer space: feasibility assessments of encapsulated freeze-dried probiotics during 1 month’s storage on the International Space Station

机译：益生菌进入外太空：在1个月的国际空间站储存期间对封装的冷冻干燥益生菌的可行性评估

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Suppression of immune function during long spaceflights is an issue that needs to be overcome. The well-established probiotic Lactobacillus casei strain Shirota (LcS) could be a promising countermeasure, and we have launched a project to investigate the efficacy of its use on the International Space Station (ISS). As a first step, we developed a specialist probiotic product for space experiments, containing freeze-dried LcS in capsule form (Probiotics Package), and tested its stability through 1 month of storage on the ISS. The temperature inside the ISS ranged from 20.0 to 24.5?°C. The absorbed dose rate of the flight sample was 0.26 mGy/day and the dose equivalent rate was 0.52?mSv/day. The number of live LcS was 1.05?×?1011 colony-forming units/g powder (49.5% of the initial value) 6 months after the start of the study; this value was comparable to those in the two ground controls. Profiles of randomly amplified polymorphic DNA, sequence variant frequency, carbohydrate fermentation, reactivity to LcS-specific antibody, and the cytokine-inducing ability of LcS in the flight sample did not differ from those of the ground controls. We can therefore maintain the viability and basic probiotic properties of LcS stored as a Probiotics Package on the ISS.
机译：在长空间环境中抑制免疫功能是需要克服的问题。良好良好的益生菌乳杆菌酪蛋白菌株Shirota（LCS）可能是一个很有希望的对策，我们已经推出了一个项目来调查其在国际空间站（ISS）上使用的功效。作为第一步，我们开发了一种专业益生菌产品，用于空间实验，含有胶囊形式的冷冻干燥LCS（益生菌包装），并通过1个月的ISS储存来测试其稳定性。 IS内的温度范围为20.0至24.5°C。飞行样品的吸收剂量率为0.26变化/天，剂量当量率为0.52Ω·mSV /天。实时LCS的数量为1.05？×1011菌落形成单位/ G粉末（初始值的49.5％）开始后6个月;该值与两个地面控制中的值相当。随机扩增的多态DNA，序列变异频率，碳水化合物发酵，对LCS特异性抗体的反应性的谱，以及飞行样品中LCS的细胞因子诱导能力与地面对照的不同之处没有不同。因此，我们可以在ISS上维持储存作为益生菌包装的LCs的可行性和基本益生菌特性。

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