DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

Giusi Russo; Rosaria Landi; Antonio Pezone; Annalisa Morano; Candida Zuchegna; Antonella Romano; Mark T. Muller; Max E. Gottesman; Antonio Porcellini; Enrico V. Avvedimento

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DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

机译：DNA损伤和修复修饰靶向基因座的DNA甲基化和染色质结构域：等位基因甲基化多态性机制

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We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chromatin loops connecting the 5' and 3' ends of the repaired gene. During a two-week period after repair, transcription-associated demethylation promoted by Base Excision Repair enzymes further modifies methylation of the repaired DNA. Subsequently, the repaired genes display stable but diverse methylation profiles. These profiles govern the levels of expression in each clone. Our data argue that DNA methylation and chromatin remodelling induced by HR may be a source of permanent variation of gene expression in somatic cells.

机译：我们在同源DNA修复（HR）期间和之后的染色质结构，DNA甲基化和转录的变化表征。我们发现HR改变了修复的段的DNA甲基化图案。通过诱导修复基因的5'和3'末端的DNA-染色质回路，HR也改变了局部组蛋白H3甲基化。在修复后的两周期内，由基本切除修复酶促进的转录相关的去甲基化进一步改变修复的DNA的甲基化。随后，修复的基因显示稳定但多样化的甲基化型材。这些配置文件管理每个克隆中的表达水平。我们的数据认为，HR诱导的DNA甲基化和染色质重塑可以是体细胞中基因表达的永久变化的源。

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《Scientific reports.》 |2016年第1期|共页
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Giusi Russo; Rosaria Landi; Antonio Pezone; Annalisa Morano; Candida Zuchegna; Antonella Romano; Mark T. Muller; Max E. Gottesman; Antonio Porcellini; Enrico V. Avvedimento;
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机译：有机金属光核酸酶。 I.通过环戊二烯基金属配合物的光解来切割DNA：通过CpW（CO）3CH3进行断裂的机理研究和序列选择性。二。 SWI / SNF利用CpW（CO）3CH3进行染色质结构足迹测定和染色质重塑。三， MoX（eta3-烯丙基）（CO）3（phen）复合物对DNA的双重破坏机制。
6. DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism [O] . Giusi Russo, Rosaria Landi, Antonio Pezone, -1

机译：DNA损伤和修复修饰靶向位点的DNA甲基化和染色质结构域：等位基因甲基化多态性的机制
7. DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism [O] . Russo, Giusi, Landi, Rosaria, Pezone, Antonio, 2016

机译：DNa损伤和修复修改靶向基因座的DNa甲基化和染色质结构域：等位基因甲基化多态性的机制

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

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