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DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

机译：DNA损伤和修复修饰靶向位点的DNA甲基化和染色质结构域：等位基因甲基化多态性的机制

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We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chromatin loops connecting the 5′ and 3′ ends of the repaired gene. During a two-week period after repair, transcription-associated demethylation promoted by Base Excision Repair enzymes further modifies methylation of the repaired DNA. Subsequently, the repaired genes display stable but diverse methylation profiles. These profiles govern the levels of expression in each clone. Our data argue that DNA methylation and chromatin remodelling induced by HR may be a source of permanent variation of gene expression in somatic cells.

机译：我们表征同源DNA修复（HR）期间和之后染色质结构，DNA甲基化和转录的变化。我们发现人力资源部修改了修复段的DNA甲基化模式。 HR还通过诱导连接修复基因5'和3'末端的DNA染色质环来改变局部组蛋白H3甲基化以及染色质结构。在修复后的两周内，碱基切除修复酶促进的转录相关脱甲基化进一步修饰了修复后的DNA的甲基化。随后，修复的基因显示出稳定但多样的甲基化曲线。这些配置文件控制着每个克隆的表达水平。我们的数据认为，HR诱导的DNA甲基化和染色质重塑可能是体细胞中基因表达永久变化的来源。

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期刊名称 Scientific Reports
作者
Giusi Russo; Rosaria Landi; Antonio Pezone; Annalisa Morano; Candida Zuchegna; Antonella Romano; Mark T. Muller; Max E. Gottesman; Antonio Porcellini; Enrico V. Avvedimento;
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年(卷),期 -1(6),-1
年度 -1
页码 33222
总页数 14
原文格式 PDF
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1. DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism [J] . Giusi Russo, Rosaria Landi, Antonio Pezone, Scientific reports. . 2016,第1期

机译：DNA损伤和修复修饰靶向基因座的DNA甲基化和染色质结构域：等位基因甲基化多态性机制
2. The influence of polymorphisms of xenobiotic-metabolizing and DNA repair genes in DNA damage, telomere length and global DNA methylation evaluated in open-cast coal mining workers [J] . de Souza Melissa Rosa, Rohr Paula, Silva Kahl Vivian Francilia, Ecotoxicology and Environmental Safety . 2020,第Feba期

机译：露天煤矿工人评估异种代谢和DNA修复基因多态性对DNA损伤，端粒长度和总体DNA甲基化的影响
3. Association of BER and NER pathway polymorphism haplotypes and micronucleus frequencies with global DNA methylation in benzene-exposed workers of China Effects of DNA repair genes polymorphisms on genetic damage [J] . Zhang Guang-hui, Ren Jing-chao, Luo Mengkai, Mutation Research - Genetic Toxicology and Environmental Mutagenesis . 2019,第期

机译：BER和NER途径多态性单倍型和微核频率与全球DNA甲基化的苯暴露工人在DNA修复基因多态性对遗传破坏中的影响
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Organometallic photonucleases. I. DNA cleavage by the photolysis of cyclopentadienyl metal complexes: Mechanistic studies and sequence selectivity of strand scission by CpW(CO)3CH3. II. Footprinting of chromatin structure and chromatin remodeling by SWI/SNF utilizing CpW(CO)3CH3. III. Dual mechanisms of DNA damage by MoX(eta3-allyl)(CO)3(phen) complexes. [D] . Downs, Jennifer. 2005

机译：有机金属光核酸酶。 I.通过环戊二烯基金属配合物的光解来切割DNA：通过CpW（CO）3CH3进行断裂的机理研究和序列选择性。二。 SWI / SNF利用CpW（CO）3CH3进行染色质结构足迹测定和染色质重塑。三， MoX（eta3-烯丙基）（CO）3（phen）复合物对DNA的双重破坏机制。
6. Developmental Profile of H19 Differentially Methylated Domain (DMD) Deletion Alleles Reveals Multiple Roles of the DMD in Regulating Allelic Expression and DNA Methylation at the Imprinted H19/Igf2 Locus [O] . Joanne L. Thorvaldsen, Andrew M. Fedoriw, Son Nguyen, 2006

机译：H19差异甲基化域（DMD）缺失等位基因的发展概况揭示了DMD在调控等位基因表达和印迹的H19 / Igf2基因座DNA甲基化中的多重作用。
7. DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism [O] . Russo, Giusi, Landi, Rosaria, Pezone, Antonio, 2016

机译：DNa损伤和修复修改靶向基因座的DNa甲基化和染色质结构域：等位基因甲基化多态性的机制

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

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