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首页> 外文期刊>Scientific reports. >Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trial
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Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trial

机译：含季铵甲基丙烯酰氧基含硅酸硅树脂的抗微生物活性：随机临床试验

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Quaternary ammonium methacryloxy silicate (QAMS)-containing acrylic resin demonstrated contact-killing antimicrobial ability in vitro after three months of water storage. The objective of the present double-blind randomised clinical trial was to determine the in vivo antimicrobial efficacy of QAMS-containing orthodontic acrylic by using custom-made removable retainers that were worn intraorally by 32 human subjects to create 48-hour multi-species plaque biofilms, using a split-mouth study design. Two control QAMS-free acrylic disks were inserted into the wells on one side of an orthodontic retainer, and two experimental QAMS-containing acrylic disks were inserted into the wells on the other side of the same retainer. After 48 hours, the disks were retrieved and examined for microbial vitality using confocal laser scanning microscopy. No harm to the oral mucosa or systemic health occurred. In the absence of carry-across effect and allocation bias (disks inserted in the left or right side of retainer), significant difference was identified between the percentage kill in the biovolume of QAMS-free control disks (3.73 ± 2.11%) and QAMS-containing experimental disks (33.94 ± 23.88%) retrieved from the subjects (P ≤ 0.001). The results validated that the QAMS-containing acrylic exhibits favourable antimicrobial activity against plaque biofilms in vivo. The QAMS-containing acrylic may also be used for fabricating removable acrylic dentures.
机译：季铵甲基丙烯酰氧基硅酸盐（QAMS） - 丙烯酸树脂在储水中三个月后体外展示接触抗菌能力。目前双盲随机临床试验的目的是通过使用32人受试者穿过32人对外佩戴的定制可移除的固定器来确定含QAM的含QAM的抗微生物功效32人受试者以产生48小时的多种斑块生物膜，使用分嘴研究设计。将两种对照Qams的丙烯酸块插入正畸保持器一侧的孔中，并且将含有两个实验QAMS的丙烯酸块插入相同保持器的另一侧的孔中。 48小时后，使用共聚焦激光扫描显微镜检索并检查磁盘并检查微生物活力。对口腔粘膜或系统健康没有危害。在没有携带的效果和分配偏差（插入左侧或右侧的左侧或右侧的磁盘）中，在无QAMS的QAMS的杀虫剂中杀死百分比之间鉴定了显着的差异（3.73±2.11％）和QAM - 从受试者中检索的实验盘（33.94±23.88％）（p≤0.001）。结果验证了含有QAMS的丙烯酸类药物对体内斑块生物膜具有良好的抗微生物活性。含QAMS的丙烯酸也可用于制造可去除丙烯酸牙本质假牙。

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