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首页> 外文期刊>Scientific reports. >Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors
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Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors

机译：FineGoldia属的泛基因组分析鉴定了两个不同的碎片，菌株特异性异质性和推定的毒力因子

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Finegoldia magna, a Gram-positive anaerobic coccus, is an opportunistic pathogen, associated with medical device-related infections. F. magna is the only described species of the genus Finegoldia. We report the analysis of 17 genomes of Finegoldia isolates. Phylogenomic analyses showed that the Finegoldia population can be divided into two distinct clades, with an average nucleotide identity of 90.7%. One clade contains strains of F. magna, whereas the other clade includes more heterogeneous strains, hereafter tentatively named “Finegoldia nericia”. The latter species appears to be more abundant in the human microbiome. Surface structure differences between strains of F. magna and “F. nericia” were detected by microscopy. Strain-specific heterogeneity is high and previously identified host-interacting factors are present only in subsets of “F. nericia” and F. magna strains. However, all genomes encode multiple host factor-binding proteins such as albumin-, collagen-, and immunoglobulin-binding proteins, and two to four copies of CAMP (Christie-Atkins-Munch-Petersen) factors; in accordance, most strains show a positive CAMP reaction for co-hemolysis. Our work sheds new light of the genus Finegoldia and its ability to bind host components. Future research should explore if the genomic differences identified here affect the potential of different Finegoldia species and strains to cause opportunistic infections.
机译：FineGoldia Magna是一种革兰氏阳性的厌氧Coccus，是一种与医疗器械相关的感染相关的机会主义病原体。 F. MAGNA是MENTGOLDIA属的唯一描述的物种。我们报告了对细菌植物17种基因组的分析。系统核糖组织分析表明，细杆菌人群可分为两个不同的枝条，平均核苷酸同一性为90.7％。一个人含有F.Mmona的菌株，而另一个思工包括更多的异质菌株，下文暂时命名为“FineGoldia Nericia”。后一种物种在人类微生物组中似乎更加丰富。 F. Magna和“F”菌株之间的表面结构差异。通过显微镜检测Nericia“。特定于应变的异质性高，并且先前鉴定的宿主相互作用因子仅存在于“F”的子集中存在。 Nericia“和F.Magna菌株。然而，所有基因组都编码多个宿主因子结合蛋白，如白蛋白，胶原和免疫球蛋白结合蛋白，以及两到四个营地（Christie-Atkins-Munch-Petersen）因素;根据，大多数菌株显示出用于共溶的阳性反应。我们的作品揭示了Metegoldia属的新光及其结合主机组件的能力。如果此处鉴定的基因组差异影响不同的FineGoldia物种和菌株导致机会性感染的潜力，则应探索未来的研究。

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