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首页> 外文期刊>Bioengineered >Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics
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Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics

机译：基于生物信息学的胃癌胶原型Xα1（COL10A1）表达及预后意义分析

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Collagen type X alpha 1 (COL10A1) is a member of the collagen family and the main matrix component. However, COL10A1 expression and prognosis relationship remains unclear in gastric cancer (GC). Through the analysis of database of Oncomine, the Cancer Genome Atlas (TCGA) as well as the Gene Expression Omnibus (GEO), in contrast to the tissue of normal gastric, COL10A1 in gastric cancer, had been upregulated. The high expression of COL10A1 was obviously related to T stage (P = 0.025) and lymph node metastasis (P = 0.025). It has been illustrated by the analysis of logistic regression that COL10A1’s heightened expression in gastric cancer had been essentially linked with pathological stage, tumor differentiation, and T classification. The Kaplan–Meier curve in the Kaplan-Meier plotter database (P = 0.0371) and GSE84437 (P = 0.002) indicate that patients with high COL10A1 expression possess poor prognosis, specifically GC patients with lymph node metastasis have it. TCGA’s Multivariate analysis (P = 0.025) and GSE84437 dataset (P = 0.034) show that high expression COL10A1 is a key independent predictor of poor overall survival. Searching KEGG pathway enrichment by GSEA, the results suggested that 29 pathways were enriched. qRT-PCR technique was used for verification of the COL10A1’s high expression in gastric cancer in contrast to the normal gastric tissues. In conclusion, COL10A1 is of great importance in predicting the survival rate of GC patients.
机译：胶原蛋白X alpha 1（Col10A1）是胶原蛋白家族和主矩阵组件的成员。然而，COL10A1表达和预后关系仍不清楚胃癌（GC）。通过对oncomine的数据库，癌症基因组（TCGA）以及基因表达Omnibus（Geo）与胃癌中的正常胃癌组织相比，已经上调。 COL10A1的高表达明显到T阶段（ P = 0.025）和淋巴结转移（ P = 0.025）。通过分析逻辑回归的分析，即COL10A1在胃癌中的增强表达与病理阶段，肿瘤分化和T分类基本上是相关的。 Kaplan-Meier绘图仪数据库中的Kaplan-Meier曲线（ p = 0.0371）和Gse84437（ p = 0.002）表明高COL10A1表达的患者预后具有差，特别是GC患者淋巴结转移。 TCGA的多变量分析（ P = 0.025）和GSE84437数据集（ P = 0.034）表明，高表达COL10A1是整体存活差的关键独立预测因子。通过GSEA搜索Kegg途径浓缩，结果表明，富集了29条途径。 QRT-PCR技术用于验证Col10A1在胃癌中的高表达与正常胃组织相比。总之，Col10A1在预测GC患者的存活率方面具有重要意义。

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