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首页> 外文期刊>Balkan journal of medical genetics: BJMG >Chronic obstructive pulmonary disease risk and smoking cessation changes induced by CHRNA5-A3 and CHRNB3-A6 variation in a Chinese male population
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Chronic obstructive pulmonary disease risk and smoking cessation changes induced by CHRNA5-A3 and CHRNB3-A6 variation in a Chinese male population

机译：ChrNA5-A3和ChrNB3-A6在中国男性人群中诱导的慢性阻塞性肺部疾病风险和吸烟变化

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Most studies in the field of CHRNA5-A3 and CHRNB3-A6 have only focused on lung cancer risk; however, the associations with chronic obstructive pulmonary disease (COPD) risk and smoking cessation is less understood, particularly in the Chinese male population. In this study, samples from 823 male patients with COPD (non smokers: 416; still smoking: 407) and 435 smoking male healthy control subjects were performed with DNA extraction and single nucleotide polymorphism (SNP) genotyping. We studied three SNPS in two genes, namely rs667282 and rs3743073 in CHRNA5-A3 and rs4950 in CHRNB3-A6, and their distributions in the three groups are not statistically different (p 0.05). We grouped COPD patients according to whether they had successfully quit smoking, the CT genotype of rs667282 demonstrated association with an increased rate of successful smoking cessation compared with the TT genotype [adjusted odds ratio (OR) = 0.54, 95% confidence interval (95% CI) = 0.37-0.7, p 0.001); rs4950 AG genotypes were distinctly associated with increased rates of successful smoking cessation (adjusted OR = 0.55, 95% CI = 0.40-0.76, p 0.001). The effect is significant under the assumption of an over dominant mode of inheritance (adjusted OR = 0.58, 95% CI = 0.43 to 0.79, p 0.001). No significant difference in rs3743073 was found (p 0.05). Our findings confirmed the hypothesis that CHRNA5-A3 and CHRNB3-A6 variation are not associated with the risk of COPD. We found CHRNA5-A3 and CHRNB3-A6 were significantly associated with successful smoking cessation in smoking COPD patients.
机译：Chrna5-A3和Chrnb3-A6领域的大多数研究仅重点关注肺癌风险;然而，慢性阻塞性肺病（COPD）风险和吸烟的关联较少理解，特别是在中国男性人群中。在这项研究中，使用DNA提取和单核苷酸多态性（SNP）基因分型进行823名男性患者（非吸烟者：416;仍然吸烟：407）和435次吸烟男性健康对照受试者。我们在两种基因中研究了三个SNP，即ChrnB3-A6的Chrna5-A3和RS4950中的RS667282和RS3743073，三组的分布在统计学上没有（P> 0.05）。我们分组COPD患者是否已成功戒烟，RS667282的CT基因型展示了与TT基因型相比的成功吸烟率增加的关联[调整后的差异（或）= 0.54,95％置信区间（95％ CI）= 0.37-0.7，P <0.001）; RS4950 AG基因型与成功的吸烟率较高明显相关（调节或= 0.55,95％CI = 0.40-0.76，P <0.001）。在过度的遗传模式（调节或= 0.58,95％CI = 0.43至0.79，P <0.001）的情况下，效果是显着的。发现RS3743073没有显着差异（p> 0.05）。我们的研究结果证实了ChrNA5-A3和ChrNB3-A6变异与COPD风险无关的假设。我们发现Chrna5-A3和ChrNB3-A6与吸烟COPD患者的成功停止显着相关。

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