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首页> 外文期刊>BMC Ophthalmology >Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China
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Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China

机译：视网膜血管异常及其与心血管血管疾病的关联：中国农村哈尔滨市农村研究

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Limited data is available on retinal vessel morphology in the north China. The study aimed to evaluate the prevalence of retinal vascular abnormalities (RVAs) and investigate their associations with the self-reported diagnosis of cardiovascular and cerebrovascsular diseases (CCVds) in a rural adult population of northeast China. A population-based, cross-sectional study was conducted, using the cluster random sampling method. One eye of each participant was photographed with a non-mydriatic fundus camera. RVAs including focal and general arteriolar narrowing (FAN and GAN), arteriovenous nicking (AVN), arteriolar sheathing (AS), and retinopathy were evaluated. Data on self-reported diagnosis of cardiovascular and cerebrovascular diseases and status of smoking and alcohol drinking were obtained from questionnaires. Among the 6267 participants with an age?≥?50?years, photographs were obtained of 99.2%, with quality sufficient to perform retinal evaluations in 82.5%. The prevalence of FAN, AVN, AS, retinopathy and GAN were 9.1, 8.9, 5.0, 6.6 and 6.2%, respectively. All the retinal lesions were associated with hypertension (all P??0.01). After adjusting for age, gender, and left/right eyes, hypertension, hyperlipidaemia, diabetes mellitus, habits of past or current smoking and alcohol consumption, AVN was strongly associated with the self-reported diagnosis histories of coronary heart diseases(CHD) (OR, 1.44; 95% CI, 1.09, 1.89) and retinopathy was significantly associated with a self-reported diagnosis of stroke (OR, 2.05; 95% CI, 1.18, 3.57). The overall prevalence of retinal microvascular abnormalities in this population was relatively higher than that reported in other regions of the world. Retinopathy is associated with the self-reported diagnosis of stroke while AVN was associated with the self-reported diagnosis of CHD, but the remaining retinal lesions were not consistently associated with CCVds. Thus, an examination of retinal microvascular characteristics may offer clues to CCVds and could be a potentially novel biomarkers for CCVds risk.
机译：北方视网膜血管形态有限。该研究旨在评估视网膜血管异常（RVA）的患病率，并在东北农村成年人群中调查其与自我报告的心血管和脑遗传疾病（CC​​VDS）的诊断。使用簇随机抽样方法进行基于群体的横截面研究。每位参与者的一只眼睛用非瞳孔眼底相机拍摄。评价包括焦平和通用术狭窄（风扇和GaN），动静脉切口（AVN），动脉杆菌护套（AS）和视网膜病变的RVA。关于自我报告的心血管和脑血管疾病和吸烟地位和酒精饮酒的数据的数据是从问卷中获得的。在6267年的参与者中，年龄≥10？五年，照片获得99.2％，质量足以在82.5％中进行视网膜评估。风扇，AVN，视网膜病变和GaN的患病率分别为9.1,8.9,5.0,6.6和6.2％。所有视网膜病变与高血压有关（所有P？<β01）。调整年龄，性别和左/右眼，高血压，高脂血症，糖尿病，过去或目前吸烟和饮酒的习惯，AVN与冠心病（CHD）的自我报告的诊断历史强烈关联（或，1.44; 95％CI，1.09,1.89）和视网膜病明显与自我报告的中风诊断（或2.05; 95％CI，1.18,3.57）有显着相关。这种人群视网膜微血管异常的总体患病率比在世界其他地区报告的患者相对较高。视网膜病患者与中风的自我报告的诊断有关，而AVN与CHD的自我报告的诊断有关，但剩余的视网膜病变与CCVDS不始终如一。因此，对视网膜微血管特性的检查可以向CCVDS提供线索，并且可以是用于CCVDS风险的潜在新的生物标志物。

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