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首页> 外文期刊>Journal of Sport and Health Science >The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension: Findings from the Prospective Urban Rural Epidemiology China Study
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The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension: Findings from the Prospective Urban Rural Epidemiology China Study

机译：具有高血压人的心血管疾病和全导致死亡率的握力与血管疾病的关联：从前瞻性城乡流行病学中国研究的调查结果

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BackgroundBoth hypertension and grip strength (GS) are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to affect CVD and all-cause mortality is unknown. This study sought to investigate the associations of GS with the risk of major CVD incidence, CVD mortality, and all-cause mortality in patients with hypertension.MethodsGS was measured using a Jamar dynamometer (Sammons Preston, Bolingbrook, IL, USA) in participants aged 35–70 years from 12 provinces included in the Prospective Urban Rural Epidemiology China Study. Cox frailty proportional hazards models were used to examine the associations of GS and hypertension and the outcomes of all-cause mortality and CVD incidence/mortality.ResultsAmong 39,862 participants included in this study, 15,964 reported having hypertension, and 9095 had high GS at baseline. After a median follow-up of 8.9 years (interquartile range, 6.7–9.9 years), 1822 participants developed major CVD, and 1250 deaths occurred (388 as a result of CVD). Compared with normotensive participants with high GS, hypertensive patients with high GS had a higher risk of major CVD incidence (hazard ratio (HR)?=?2.39; 95% confidence interval (95%CI): 1.86–3.06;p< 0.001) or CVD mortality (HR?=?3.11; 95%CI: 1.59–6.06;p< 0.001) but did not have a significantly increased risk of all-cause mortality (HR?=?1.24; 95%CI: 0.92–1.68;p?=?0.159). These risks were further increased if hypertensive participants whose GS level was low (major CVD incidence, HR?=?3.31, 95%CI: 2.60–4.22,p< 0.001; CVD mortality, HR?=?4.99, 95%CI: 2.64–9.43,p< 0.001; and all-cause mortality, HR?=?1.93, 95%CI: 1.47–2.53,p< 0.001).ConclusionThe present study demonstrates that low GS is associated with the highest risk of major CVD incidence, CVD mortality, and all-cause mortality among hypertensive patients. High levels of GS appear to mitigate long-term mortality risk among hypertensive patients.
机译：背景干燥的高血压和握力（GS）是死亡率和心血管疾病（CVD）的预测因子，但这些风险因素是否相互作用，而且所有原因死亡率都未知。本研究试图调查GS与高血压患者的主要CVD发病率，CVD死亡率和全因死亡率的风险的研究。使用Jamar测功机（Sammons Preston，IL，USA）在老年人的参与者中测量了方法从12个省份包括预期城乡流行病学中国研究的35-70岁。 Cox Freaigort危险模型用于检查GS和高血压的关联以及全因死亡率和CVD发病率/死亡率的结果。本研究中包含的参与者，15,964名具有高血压，9095年在基线下患有高GS。在中位出现后的8.9岁（四分位数，6.7-9岁），1822年参与者开发了主要的CVD，发生了1250人死亡（由于CVD而388）。与高GS的正常参与者相比，高GS的高血压患者具有更高的主要CVD发病率（危害比（HR）？=？2.39; 95％置信区间（95％CI）：1.86-3.06; P <0.001）或CVD死亡率（HR？= 3.11; 95％CI：1.59-6.06; P <0.001）但没有显着增加的全导致死亡率的风险（HR？= 1.24; 95％CI：0.92-1.68; p？=？0.159）。如果GS水平低的高血压参与者（主要CVD发病率，HR？3.31,95％CI：2.60-4.22，P <0.001; CVD死亡率，HR？=？4.99,95％CI：2.64 -9.43，p <0.001;和全部原因死亡率，HR？=？1.93,95％CI：1.47-2.53，P <0.001）。结论本研究表明，低GS与主要CVD发病率的最高风险相关，高血压患者的CVD死亡率和全导致死亡率。高水平的GS似乎在高血压患者中减轻了长期死亡率风险。

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