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首页> 外文期刊>BMC Endocrine Disorders >Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report
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Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report

机译：自身免疫多奇综合征2型和自身免疫性肝炎患有胸腺瘤相关的肌肌瘤，案例报告

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摘要

Autoimmune polyglandular syndrome type 2 (APS-2) is a rare and complex clinical entity, and little is known about its etiology and progression. A 52-year-old woman with autoimmune hepatitis (AIH) and bronchial asthma was diagnosed with APS-2; autoimmune Addison’s disease (AD), and Hashimoto’s thyroiditis (HT), and she underwent prednisolone (PSL) treatment. Five months later, she presented ptosis and was diagnosed with thymoma-associated myasthenia gravis (MG). Thymectomy and PSL treatment with immuno-suppressants appeared to ameliorate MG, AD, AIH, HT, and bronchial asthma. HLA typing analysis revealed that the patient had susceptible HLA alleles to MG, AIH, and HT in a Japanese population. This case suggests common endocrinological and autoimmune aspects of APS-2 and AIH with thymoma-associated MG, which are considered to be extremely rare complications.
机译：自身免疫性多沟综合征2型（APS-2）是一种难得和复杂的临床实体，并且关于其病因和进展知之甚少。有一个52岁的女性，具有自身免疫性肝炎（AIH）和支气管哮喘患有APS-2; Autoimmune Addison的疾病（AD）和Hashimoto的甲状腺炎（HT），以及她接受泼尼松（PSL）治疗。五个月后，她介绍了脑病，并被诊断患有胸腺瘤相关的肌肌肌瘤（Mg）。用免疫抑制剂的胸膜切除和PSL处理似乎是改善MG，AD，AIH，HT和支气管哮喘。 HLA键入分析显示，患者对MG，AIH和HT中的HLA等位基因含有易感HLA等位基因。这种情况表明，APS-2和AIH的常见内分泌和自身免疫方面与胸腺瘤相关的MG，其被认为是极其罕见的并发症。

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