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首页> 外文期刊>BMC Gastroenterology >Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis
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Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis

机译：用于治疗急性上部非变性胃肠道出血的临床结果：系统评价和荟萃分析

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Conventional endoscopic treatments can’t control bleeding in as many as 20% of patients with non-variceal gastrointestinal (GI) bleeding. Recent studies have shown that over-the-scope-clip (OTSC) system allowed for effective hemostasis for refractory GI bleeding lesions. So we aimed to conduct a systematic review to evaluate the effectiveness and safety of the OTSC system for management of acute non-variceal upper GI bleeding. A comprehensive literature search was conducted on PubMed, EMBASE, and Cochrane Library covering the period from January 2007 to May 2019. The literature was selected independently by two reviewers according to the inclusion and exclusion criteria. The statistical analysis was carried out using Comprehensive Meta-Analysis software version 3.0. A total of 16 studies including 769 patients with 778 GI bleeding lesions were identified. Pooled technical success was achieved in 761 lesions [95.7%; 95% confidence interval (CI), 93.5–97.2%], and the pooled clinical success was achieved in 666 lesions (84.2, 95% CI, 77.4–89.2%). The incidence of re-bleeding was reported in 81 patients and the post-procedure mortality was 10.9% (n?=?84). Only 2 (0.3%) patients occurred complications after OTSC system procedure. Our study demonstrated that the OTSC system was a technically feasible modality and highly efficacious in achieving hemostasis in acute non-variceal upper gastrointestinal bleeding.
机译：常规内窥镜治疗不能在多达20％的非变体胃肠道（GI）出血的患者中进行渗出。最近的研究表明，过度范围剪辑（OTSC）系统允许用于难治性Gi出血病变的有效止血。因此，我们旨在进行系统审查，以评估OTSC系统的效果和安全性，用于管理急性非静脉血上GI出血。覆盖2019年1月至2019年5月的PubMed，Embase和Cochrane图书馆进行了全面的文献搜索。根据包含和排除标准，由两名审稿人独立选择。使用全面的Meta-Analysis软件3.0进行统计分析。鉴定了共有16项研究，其中包括769例778种GI出血病变。汇集技术成功在761病变中取得了[95.7％; 95％置信区间（CI），93.5-97.2％]和合并的临床成功是在666个病变中获得的（84.2,95％CI，77.4-89.2％）。在81名患者中报道了重新出血的发生率，后术后死亡率为10.9％（n？=？84）。只有2（0.3％）患者在OTSC系统程序后发生并发症。我们的研究表明，OTSC系统是一种技术上可行的模态，在实现急性非变质上胃肠道出血中实现止血的高度有效。

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