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Clinical and financial burden of hospitalised community-acquired pneumonia in patients with selected underlying comorbidities in England

机译:在英格兰选定的潜在合并症患者中住院社区收购肺炎的临床和财务负担

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Background Hospitalised pneumonia may have long-term clinical and financial impact in adult patients with underlying comorbidities.Methods We conducted a retrospective cohort study using the Hospital Episode Statistics (HES) database to determine the clinical and financial burden over 3 years of hospitalised community-acquired pneumonia (CAP) to England’s National Health Service (NHS). Subjects were adults with six underlying comorbidities (chronic heart disease (CHD); chronic kidney disease (CKD); chronic liver disease (CLD); chronic respiratory disease (CRD); diabetes mellitus (DM) and post bone marrow transplant (post-BMT)) with an inpatient admission in 2012/2013. Patients with CAP in 2013/2014 were followed for 3?years and compared with similarly aged, propensity score-matched adults with the same comorbidity without CAP.Findings The RR of hospital admissions increased after CAP, ranging from 1.08 (95% CI 1.04 to 1.12) for CKD to 1.38 (95% CI 1.35 to 1.40) for CRD. This increase was maintained for at least 2?years. Mean difference in hospital healthcare costs (£) was higher for CAP patients in 2013/2014; ranging from £1115 for DM to £8444 for BMT, and remained higher for 4/6 groups for 2 more years, ranging from £1907 (95% CI £1573 to £2240) for DM to £11?167 (95% CI £10 847 to £11 486) for CRD.) The OR for mortality was significantly higher for at least 3 years after CAP, ranging from 4.76 (95% CI 4.12 to 5.51, p0.0001) for CLD to 7.50 (95%CI 4.71 to 11.92, p0.0001) for BMT.Interpretation For patients with selected underlying comorbidities, healthcare utilisation, costs and mortality increase for at least 3?years after being hospitalised CAP.
机译:背景,住院肺炎可能对成年患者有长期的临床和财务影响,患有潜在的合并症。我们使用医院阶段统计(HES)数据库进行了一项回顾性的队列研究,以确定3年住院社区获得的临床和金融负担肺炎(盖子)到英格兰的国家卫生服务(NHS)。受试者是患有六种潜在的合并症的成年人(慢性心脏病(CHD);慢性肾病(CKD);慢性肝病(CLD);慢性呼吸道疾病(CRD);糖尿病(DM)和后骨髓移植后(BMT后骨髓移植) ))2012/2013年的住院入住。 2013/2014年持续患者3年,与类似的老年人相比,倾向分数匹配的成年人,具有相同的合并症,具有相同的合并症。帽子的RR在帽子后增加,范围从1.08(95%CI 1.04)增加(95%CI 1.04 1.12)对于CRD的CKD至1.38(95%CI 1.35至1.40)。这种增加保持至少2年。 2013/2014年CAP患者的医院医疗费用(£)的平均差异更高;为BMT的DM至8444英镑的价格从1115英镑到8444英镑,4/6组持续2年,从1907年的£1907(95%CI£1573到2240英镑)到11英镑?167(95%CI CRD的10,0847至11466英镑)。)CAC帽的盖子或死亡率明显高出3年,从4.76(95%CI 4.12至5.51,P <0.0001),用于CLD至7.50(95%CI 4.71至11.92,p <0.0001)用于BMT.患者为潜在的潜在机理,医疗保健利用率,成本和死亡率增加至少3岁以下的患者,住院治疗帽后数年。

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