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首页> 外文期刊>BMC Infectious Diseases >Hepatitis C screening, diagnosis, and cascade of care among people aged ?40?years in Brasilia, Brazil
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Hepatitis C screening, diagnosis, and cascade of care among people aged ?40?years in Brasilia, Brazil

机译：丙型肝炎筛选，诊断和级联的人员在岁月中> 40？40？在巴西巴西的岁月

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Identifying patients with hepatitis C virus (HCV) infection and enhancing the cascade of care are essential for eliminating HCV infection. This study aimed to estimate the prevalence of positive anti-HCV serology in Brasilia, Brazil, and evaluate the efficiency of the cascade of care for HCV-positive individuals. This cross-sectional study analyzed 57,697 rapid screening tests for hepatitis C in individuals aged ?40?years between June 2018 and June 2019. HCV-positive patients were contacted and scheduled to undergo the HCV RNA viral test, genotyping, and transient elastography. The prevalence of positive serology was 0.27%. Among 161 patients with positive anti-HCV serology, 124 (77%) were contacted, 109 (67.7%) were tested for HCV RNA viral load, and 69 (42.8%) had positive results. Genotype 1 (75%) was the most prevalent genotype. Among 65 patients (94.2%) who underwent transient elastography, 30 (46.2%) presented with advanced fibrosis. Additionally, of the 161 patients, 55 (34.1%) were referred for treatment, but only 39 (24.2%) complied, with 36 (22.4%) showing sustained virological response. By the end of the study, 16 patients were still awaiting to receive medication. The prevalence of HCV-positive patients was low in Brasilia, and the gaps in the cascade of care for these patients were significantly below the targets of HCV infection elimination. This study opens new avenues for eliminating HCV infection and suggests that partnerships with clinical laboratories to conduct anti-HCV tests are a useful strategy to improve HCV diagnosis. Research Ethics Committee of the Faculty of Health Sciences of the University of Brasília - UNB (CAAE number 77818317.2.0000.0030) and by the Ethics Committee of the Health Science Teaching and Research Foundation - FEPECS/SES/DF (CAAE number 77818317.2.3001.5553).
机译：鉴定丙型肝炎病毒（HCV）感染的患者和增强级联的级联对于消除HCV感染是必不可少的。本研究旨在估算巴西氏菌，巴西阳性抗HCV血清学的患病率，评价HCV阳性个体级联的级联效率。这种横截面研究分析了57,697岁的丙型肝炎的快速筛查试验>？40岁及2019年6月期间的丙型肝炎的快速筛选试验。联系并预定HCV阳性患者进行HCV RNA病毒试验，基因分型和瞬时弹性术。阳性血清学的患病率为0.27％。在161例阳性抗HCV血清学患者中，接触124（77％），对HCV RNA病毒载量进行109（67.7％），69例（42.8％）具有阳性结果。基因型1（75％）是最普遍的基因型。在65名患者（94.2％）中，经过瞬态弹性术，30（46.2％）提出先进的纤维化。此外，在161名患者中，55名（34.1％）被提及治疗，但只有39（24.2％）符合39（22.2％），具有36（22.4％）显示持续的病毒学反应。在研究结束时，16名患者仍在等待接受药物。 HCV阳性患者的患病率在巴西利亚低，并且这些患者级联的间隙显着低于HCV感染消除的目标。本研究开启了消除HCV感染的新途径，并表明与临床实验室进行抗HCV测试的伙伴关系是改善HCV诊断的有用策略。 Supional ofBrasília-UNB（CAAE 77818317.2.0000.0030）和卫生科学教学和研究基金会的伦理委员会研究伦理委员会 - FEPECS / SES / DF（CAAE号77818317.2.3001.5553）。

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