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首页> 外文期刊>BMC Infectious Diseases >Low frequency of enterohemorrhagic, enteroinvasive and diffusely adherent Escherichia coli in children under 5?years in rural Mozambique: a case-control study
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Low frequency of enterohemorrhagic, enteroinvasive and diffusely adherent Escherichia coli in children under 5?years in rural Mozambique: a case-control study

机译：5岁以下儿童肠内饲料，肠内饲料，吞咽和漫游的大肠杆菌的低频率？在农村莫桑比克农村的岁月：一个案例对照研究

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Diarrheagenic Escherichia coli (DEC) are among the leading pathogens associated with endemic diarrhea in low income countries. Yet, few epidemiological studies have focused the contribution of enterohemorrhagic E. coli (EHEC), enteroinvasive E. coli (EIEC) and diffusely adherent E. coli (DAEC). We assessed the contribution of EHEC, EIEC and DAEC isolated from stool samples from a case-control study conducted in children aged ?5?years in Southern Mozambique between December 2007 and November 2012. The isolates were screened by conventional PCR targeting stx1 and stx2 (EHEC), ial and ipaH (EIEC), and daaE (DAEC) genes. We analyzed 297 samples from cases with less-severe diarrhea (LSD) matched to 297 controls, and 89 samples from cases with moderate-to-severe diarrhea (MSD) matched to 222 controls, collected between November 3, 2011 and November 2, 2012. DEC were more common among LSD cases (2.7%, [8/297] of cases vs. 1.3% [4/297] of controls; p?=?0.243]) than in MSD cases (0%, [0/89] of cases vs. 0.4%, [1/222]?of controls; p?=?1.000). Detailed analysis revealed low frequency of EHEC, DAEC or EIEC and no association with diarrhea in all age strata. Although the low frequency, EIEC was predominant in LSD cases aged 24–59?months (4.1% for cases vs. 0% for controls), followed by DAEC in similar frequency for cases and controls in infants (1.9%) and lastly EHEC from one control. Analysis of a subset of samples from previous period (December 10, 2007 and October 31, 2011) showed high frequency of DEC in controls compared to MSD cases (16.2%, [25/154] vs. 11.9%, [14/118], p?=?0.383, respectively). Among these, DAEC predominated, being detected in 7.7% of cases vs. 17.6% of controls aged 24–59?months, followed by EIEC in 7.7% of cases vs. 5.9% of controls for the same age category, although no association was observed. EHEC was detected in one sample from cases and two from controls. Our data suggests that although EHEC, DAEC and EIEC are less frequent in endemic diarrhea in rural Mozambique, attention should be given to their transmission dynamics (e.g. the role on sporadic or epidemic diarrhea) considering that the role of asymptomatic individuals as source of dissemination remains unknown.
机译：DiaRReagenic Escherichia Coli（DEC）是与低收入国家的地方性腹泻有关的主要病原体。然而，很少有流行病学研究重点是肠溶大肠杆菌（EHEC），肠内血管大肠杆菌（EIEC）和弥漫性粘附的大肠杆菌（DAEC）的贡献。我们评估了EHEC，EIC和DAEC从2007年12月和2012年11月在莫桑比克南部的儿童中进行的案例对照研究中分离出粪便样本的贡献。分离株通过靶向STX1和STX2筛选（EHEC），IAL和IPAH（EIEC）和DAAE（DAEC）基因。我们将297个样品分析了297例腹泻（LSD）与297个对照率较低的腹泻（LSD）的样品，以及来自222个对照的中度至严重的腹泻（MSD）的89个样品，2011年11月3日和2012年11月2日期间收集。DEC在LSD病例中更常见（2.7％，[8/297]病例与1.3％[4/297]; p？= 0.243]）比在MSD病例（0％，[0/89] ]病例与0.4％，[1/222]？对照; p？=？1.000）。详细分析显示了EHEC，DAEC或EIEC的低频率，在所有年龄层中没有与腹泻的关系。虽然低频，eiec在24-59岁的LSD病例中占主导地位？月份（对照的情况4.1％，对照组4.1％），随后在婴幼儿（1.9％）中的案件和控制等频率（1.9％）的DAEC。一个控制。分析前期（2007年12月10日和2011年12月10日）的样本子集，与MSD病例相比，对照组的高频率为DEC（16.2％，[25/154]与11.9％，[14/118] ，p？= 0.383分别）。其中，DAEC占主导地位，在7.7％的病例中检测到24-59岁的案件中的7.6％？几个月，随后在7.7％的病例中eiec，虽然没有一个关联观察到的。从病例和两种方法中检测到eHEC。我们的数据表明，虽然EHEC，DAEC和EIEC在农村莫桑比克的地方腹泻中常见，但应注意其传播动态（例如散发性或疫情腹泻的作用）考虑到无症状个人作为传播源的作用仍然存在未知。

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