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首页> 外文期刊>Brain Sciences >Stimulus Intensity Affects Variability of Motor Evoked Responses of the Non-Paretic, but Not Paretic Tibialis Anterior Muscle in Stroke
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Stimulus Intensity Affects Variability of Motor Evoked Responses of the Non-Paretic, but Not Paretic Tibialis Anterior Muscle in Stroke

机译：刺激强度影响运动诱发的非瘫痪响应的变化，但在中风中没有瘫痪的胫骨前肌

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Background: Transcranial magnetic stimulus induced motor evoked potentials (MEPs) are quantified either with a single suprathreshold stimulus or using a stimulus response curve. Here, we explored variability in MEPs influenced by different stimulus intensities for the tibialis anterior muscle in stroke. Methods: MEPs for the paretic and non-paretic tibialis anterior (TA) muscle representations were collected from 26 participants with stroke at seven intensities. Variability of MEP parameters was examined with coefficients of variation (CV). Results: CV for the non-paretic TA MEP amplitude and area was significantly lower at 130% and 140% active motor threshold (AMT). CV for the paretic TA MEP amplitude and area did not vary with intensity. CV of MEP latency decreased with higher intensities for both muscles. CV of the silent period decreased with higher intensity for the non-paretic TA, but was in reverse for the paretic TA. Conclusion: We recommend a stimulus intensity of greater than 130% AMT to reduce variability for the non-paretic TA. The stimulus intensity did not affect the MEP variability of the paretic TA. Variability of MEPs is affected by intensity and side tested (paretic and non-paretic), suggesting careful selection of experimental parameters for testing.
机译：背景：经颅磁刺激诱导的电动机诱发电位（MEP）用单个Suprathreshold刺激或使用刺激响应曲线量化。在这里，我们探讨了受卒中中胫骨前肌的不同刺激强度影响的MEP。方法：从26名参与者在七个强度下从26名参与者收集瘫痪和非瘫痪胫骨前（TA）肌肉表示的MEP。使用变异系数（CV）检查MEP参数的可变性。结果：非静脉TA MEP幅度和面积的CV在130％和140％的活性电机阈值（AMT）下显着降低。探测器的CV对于探测器MEP幅度和区域没有强度变化。 MEP延迟的CV随着两种肌肉的强度而降低。静音时段的CV随着非剖视TA的更高强度而降低，但对剖视表示相反。结论：我们建议刺激强度大于130％，以降低非剖视TA的可变性。刺激强度不影响瘫痪TA的MEP变异性。 MEPS的可变性受强度和侧面测试的影响（窥探和非瘫痪）的影响，提示仔细选择测试的实验参数。

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