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首页> 外文期刊>BMC Nephrology >Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: a systematic scoping review
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Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: a systematic scoping review

机译：浅析慢性肾脏疾病前进进展和死亡率的少数群体差异：系统范围综述

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BACKGROUND:There are a growing number of studies on ethnic differences in progression and mortality for pre-dialysis chronic kidney disease (CKD), but this literature has yet to be synthesised, particularly for studies on mortality.METHODS:This scoping review synthesized existing literature on ethnic differences in progression and mortality for adults with pre-dialysis CKD, explored factors contributing to these differences, and identified gaps in the literature. A comprehensive search strategy using search terms for ethnicity and CKD was taken to identify potentially relevant studies. Nine databases were searched from 1992 to June 2017, with an updated search in February 2020.RESULTS:8059 articles were identified and screened. Fifty-five studies (2 systematic review, 7 non-systematic reviews, and 46 individual studies) were included in this review. Most were US studies and compared African-American/Afro-Caribbean and Caucasian populations, and fewer studies assessed outcomes for Hispanics and Asians. Most studies reported higher risk of CKD progression in Afro-Caribbean/African-Americans, Hispanics, and Asians, lower risk of mortality for Asians, and mixed findings on risk of mortality for Afro-Caribbean/African-Americans and Hispanics, compared to Caucasians. Biological factors such as hypertension, diabetes, and cardiovascular disease contributed to increased risk of progression for ethnic minorities but did not increase risk of mortality in these groups.CONCLUSIONS:Higher rates of renal replacement therapy among ethnic minorities may be partly due to increased risk of progression and reduced mortality in these groups. The review identifies gaps in the literature and highlights a need for a more structured approach by researchers that would allow higher confidence in single studies and better harmonization of data across studies to advance our understanding of CKD progression and mortality.
机译：背景：对透析前慢性肾病（CKD）的进展和死亡率的种族差异有越来越多的研究，但该文献尚未合成，特别是对死亡率的研究。方法：这项裁员审查合成现有文学关于透析前CKD的成年人的进展和死亡率的民族差异，探讨了对这些差异的影响因素，并确定了文献中的差距。采取了使用搜索条件的全面搜索策略，以确定潜在的相关研究。从1992年到2017年6月搜索了九个数据库，在2020年2月的情况下进行了更新的搜索。结果：8059篇文章被识别并筛选。本次审查中包含五十五项研究（2系统审查，7个非系统性评论和46项个人研究）。大多数人是美国学习和比较非裔美国人/美国黑人和白种人人群，以及较少的研究评估了西班牙裔和亚洲人的结果。大多数研究报告，亚非加勒比/非洲裔美国人，西班牙裔和亚洲人，亚洲人，亚洲人死亡率的风险，与白种人相比，亚洲人的死亡率和亚洲人的死亡风险降低，以及对白人人的死亡/非洲裔美国人和西班牙裔人的混合调查结果。高血压，糖尿病和心血管疾病等生物因素导致少数民族进展的风险增加，但未增加这些群体中死亡风险。结论：少数群体之间的肾脏替代治疗的较高率可能部分是由于风险增加了这些群体中的进展和降低死亡率。审查确定了文献中的差距，并强调了通过研究人员更具结构化的方法，这些方法将使对单一研究的信心更高，并更好地统一跨研究的数据，以推进我们对CKD进展和死亡的理解。

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