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首页> 外文期刊>BMC Pediatrics >Preventing academic difficulties in preterm children: a randomised controlled trial of an adaptive working memory training intervention – IMPRINT study
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Preventing academic difficulties in preterm children: a randomised controlled trial of an adaptive working memory training intervention – IMPRINT study

机译:预防早产儿的学术困难:自适应工作记忆训练干预的随机对照试验 - 印记研究

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Background Very preterm children exhibit difficulties in working memory, a key cognitive ability vital to learning information and the development of academic skills. Previous research suggests that an adaptive working memory training intervention (Cogmed) may improve working memory and other cognitive and behavioural domains, although further randomised controlled trials employing long-term outcomes are needed, and with populations at risk for working memory deficits, such as children born preterm. In a cohort of extremely preterm ( Methods/Design This double-blind, placebo-controlled, randomised controlled trial aims to recruit 126 extremely preterm/extremely low birthweight 7-year-old children. Children attending mainstream school without major intellectual, sensory or physical impairments will be eligible. Participating children will undergo an extensive baseline cognitive assessment before being randomised to either an adaptive or placebo (non-adaptive) version of Cogmed. Cogmed is a computerised working memory training program consisting of 25 sessions completed over a 5 to 7 week period. Each training session takes approximately 35 minutes and will be completed in the child’s home. Structural, diffusion and functional Magnetic Resonance Imaging, which is optional for participants, will be completed prior to and 2 weeks following the training period. Follow-up assessments focusing on academic skills (primary outcome), working memory and attention (secondary outcomes) will be conducted at 2 weeks’, 12 months’ and 24 months’ post-intervention. Discussion To our knowledge, this study will be the first randomised controlled trial to (a) assess the effectiveness of Cogmed in school-aged extremely preterm/extremely low birthweight children, while incorporating advanced imaging techniques to investigate neural changes associated with adaptive working memory training, and (b) employ long-term follow-up to assess the potential benefit of improved working memory on academic functioning. If effective, Cogmed would serve as a valuable, available intervention for improving developmental outcomes for this population. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12612000124831 .
机译:背景技术非常早产儿在工作记忆中表现出困难,这是对学习信息的关键认知能力和学术技能的发展至关重要。以前的研究表明,自适应工作记忆训练干预(CogMed)可以改善工作记忆和其他认知和行为域,尽管需要采用长期结果的进一步随机对照试验,并且有风险的群体工作记忆缺陷,如儿童出生的早产。在极度预料的队列中(方法/设计这种双盲,安慰剂控制的随机对照试验旨在招募126个非常早产/极低的出生体重7岁儿童。儿童参加主流学校,没有主要知识分子,感官或物理损伤将有资格。参与儿童将在随机进行广泛的基线认知评估,然后是随机的Adaptive或安慰剂(非适应性)版本的Cogmed。Cogmed是一个由25个会议组成的计算机化工作记忆培训计划,其中包括5到7次周期。每个培训课程大约需要35分钟,将在孩子的家中完成。对于参与者来说,适用于参与者的结构,扩散和功能磁共振成像将在培训期后和2周之前完成。随访专注于学术技能(主要结果),工作记忆和注意(二次结果)的评估将是干预后2周,12个月和24个月进行了。讨论我们的知识,本研究将是第一个随机对照审判(a)评估Cogm​​ed在学龄老年人的早产/极低出生体育儿童中的有效性,同时采用先进的成像技术来调查与适应性工作记忆训练相关的神经变化(b)雇用长期后续行动,以评估改进学业运作工作记忆的潜在好处。如果有效,CogMed将作为提高该人群的发展成果的有价值的可用干预。试验登记澳大利亚新西兰临床试验登记法ACTRN12612000124831

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