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首页> 外文期刊>Brazilian Journal of Anesthesiology >Effects of rocuronium, sugammadex and rocuronium-sugammadex complex on coagulation in rats
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Effects of rocuronium, sugammadex and rocuronium-sugammadex complex on coagulation in rats

机译：rocuronium，sugammadex和rocuronium-sugammadex复合物对大鼠凝血的影响

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Background and objectivesSugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanism of the effects on coagulation are not fully understood. The objective of this research is to evaluate the effects of rocuronium, sugammadex and the rocuronium-sugammadex complex on coagulation in an experimental model in rats.MethodsThis is an experimental randomized animal study. Wistar rats were randomly assigned into the following groups: the Control Group; the Ssal Group – 0.5mL of intravenous saline; the Sugammadex Group – intravenous sugammadex (100mgkg?1); and the Rocuronium-Sugammadex Group – intravenous solution with rocuronium (3.75mgkg?1) and sugammadex (100mgkg?1). Anesthesia was performed by using isoflurane with controlled ventilation. Coagulation factors were measured 10minutes after the end of the preoperative preparation and 30minutes after the administration of the drugs in accordance with the chosen groups.ResultsPlatelet counts, prothrombin times, and activated partial thromboplastin times were similar between the groups and between the moments within each group. There were reductions in the plasma fibrinogen levels between sample times 1 and 2 in the Rocuronium-Sugammadex group (p=0.035).ConclusionsThe rocuronium-sugammadex complex promoted reductions in plasma fibrinogen counts, although the levels were still within normal limits.
机译：背景和ObjectivessugamdAdex是一种能够逆转神经肌肉嵌段的替代药物药物，而无需抗胆碱酯酶药物呈列的限制。报道了与血糖处理相关的凝血障碍。凝血效果的确切机制尚未完全理解。该研究的目的是评估罗酮，血小糖尿和罗莫铵 - 血糖X复合物在大鼠实验模型中凝结的影响。方法是实验性随机性动物研究。 Wistar大鼠随机分配到以下组：对照组; SSAL组 - 0.5ml静脉注射盐水; sugammadex组 - 静脉注射血压（100mgkg？1）;和罗冬铵 - 血糖X组 - 静脉注射液体（3.75mgkg≤1）和慢X（100mgkg？1）。通过使用具有受控通气的异氟醚进行麻醉。在术前制剂的结束后测量凝血因子10分钟，按照所选择的群体给药后30分钟.Resultsplatelet计数，凝血酶原次数和活化的部分血栓形成蛋白次数在组之间和每组内的时刻之间相似。在罗硫铵 - - 血管氧化物组中的样品时间1和2之间的血浆纤维蛋白原水平减少（P = 0.035）。结论罗孔硫鎓 - 慢性 - 中血糖复合物的促进血浆纤维蛋白原计数中的减少，但水平仍然在正常限度范围内。

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