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A case series of concomitant burn and COVID-19

机译：一个伴随烧伤和covid-19的案例系列

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Background The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) has become a human pandemic. Heightened inflammation, vascular hyperpermeability, acute lung injury, coagulopathy, and cardiovascular abnormalities are among the SARS-CoV-2 infection-related complications. Major burn is also associated with metabolic derangements, vascular leak, and hemodynamic instability. Burn patients are at high risk for infections and developing sepsis. COVID-19 in burn victims might worsen the clinical outcome and make their medical management challenging. Result Here, we present four cases of concomitant burn and COVID-19 with different degrees of complications. They had no (three out of four) or multiple (one out of four) baseline comorbidities and all were admitted to hospital for further management. Three out of four cases demonstrated acute respiratory failure and were intubated (no longer than 7?days). It seems that one of them had COVID-19 on arrival, the other apparently contracted at outside hospital, and the last two infected during the index hospitalization. Conclusion Concomitant severe burn and COVID-19 might complicate the clinical presentation and hospital course. Such combination was associated with poor outcome in a case with baseline comorbidities, beyond what was expected from the severity of burn injury. However, a more comprehensive study with larger sample size is required to make a valid conclusion. With an ongoing COVID-19 global pandemic, SARS-CoV-2 infection might be a concurrent disease with other illnesses or traumas such as burn. This dictate multidisciplinary approaches to risk stratify, screen, assess, and manage coexisting diseases. Additionally, appropriate preparations and careful precautions need to be executed in burn units to prevent COVID-19 exposure and transmission to limit potential adverse outcomes.
机译：背景技术最近出现的严重急性呼吸综合征冠状病毒-2（SARS-COV-2）疾病（Covid-19）已成为一种人的大流行。炎症，血管超透性，急性肺损伤，凝血病和心血管异常的炎症高，炎症性血管病变，血管内异常是SARS-COV-2的感染相关的并发症。主要烧伤也与代谢紊乱，血管泄漏和血流动力学不稳定有关。烧伤患者处于高风险的感染和开发败血症。 Covid-19在烧伤受害者可能会使临床结果恶化，并使他们的医疗管理挑战。结果在此，我们呈现了四种伴随的烧伤和Covid-19，具有不同的并发症。他们没有（四分之一）或多个（四分之一）基线合并症，所有人都被录取到医院进行进一步管理。四种案例中的三种患者显示出急性呼吸衰竭，并管制（不超过7个？天）。似乎其中一个人在抵达时有Covid-19，另一个在医院外部签约，并在指数住院期间感染的最后两次感染。结论伴随着严重的烧伤和Covid-19可能使临床演示和医院课程复杂化。这种组合与基线合并症的情况差，超出了燃烧损伤严重程度的预期。然而，需要更全面的样本量的研究来进行有效的结论。随着持续的Covid-19全球大流行，SARS-COV-2感染可能是与其他疾病或烧伤等疾病或创伤的同时疾病。这决定了风险分层，屏幕，评估和管理共存疾病的多学科方法。此外，需要在燃烧单元中执行适当的准备和仔细的预防措施，以防止Covid-19暴露和传输限制潜在的不利结果。

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