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首页> 外文期刊>Cancer Management and Research >LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis
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LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis

机译：LINC01410敲低抑制宫颈癌生长和侵入，通过靶向MIR-2467-3P / Vopp1轴

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Background: Long noncoding RNAs have essential roles in human diseases, including cancer. Our work aims to assess the function and mechanisms of LINC01410 in cervical cancer (CC) development. Methods: Expression analyses were performed using qRT-PCR. Proliferation was determined through CCK8 and colony formation assays. Cell migration and invasion were determined by Transwell assay. The interactions among LINC01410, miR-2467-3p and VOPP1 were analyzed via luciferase reporter assay. Results: LINC01410 was upregulated in CC tissues and cell lines. LINC01410 upregulation correlated with poor prognosis. LINC01410 silencing suppressed proliferation, migration and invasion of CC cells. LINC01410 was the sponge for miR-2467. And LINC01410 promoted VOPP1 expression through inhibiting miR-2467. Conclusion: Our findings demonstrated that LINC01410 contributed to CC progression through regulating miR-2467/VOPP1 axis and suggested that LINC01410/miR-2467/VOPP1 cascade may be a potential therapeutic target.
机译：背景：长量不应rnas具有人类疾病的重要作用，包括癌症。我们的工作旨在评估LINC01410在宫颈癌（CC）发展中的功能和机制。方法：使用QRT-PCR进行表达分析。通过CCK8和菌落形成测定法测定增殖。通过Transwell测定确定细胞迁移和侵袭。通过Luciferase报道分析分析LINC01410，MIR-2467-3P和VOPP1之间的相互作用。结果：LINC01410在CC组织和细胞系中上调。 LINC01410上调与预后差相关。 LINC01410沉默抑制了CC细胞的增殖，迁移和侵袭。 LINC01410是MIR-2467的海绵。和LINC01410通过抑制miR-2467促进了vopp1表达。结论：我们的研究结果表明，LINC01410通过调节miR-2467 / vopp1轴来促进CC进展，并提出LINC01410 / miR-2467 / Vopp1级联可能是潜在的治疗目标。

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