...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cardiology research and practice >Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease
【24h】

Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease

机译：川崎病儿童丙氨酸氨基转移酶/天冬氨酸氨基转移酶比（AST / ALT比率）和冠状动脉损伤之间的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective. To investigate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), and coronary artery aneurysms (CAA) in children with Kawasaki disease (KD). Design. We retrospectively studied 2678 children with KD and divided them into two groups: a low-AAR group and a high-AAR group with a median AAR of 1.13 as the cut-off point. The differences in laboratory data, clinical manifestations, and coronary artery damage rates were compared between the two groups. Results. The incidence of CAL was higher in the low-AAR group than in the high-AAR group at 2 and 3-4 weeks after illness onset (p0.001, respectively). The IVIG resistance rate was significantly higher in the low-AAR group than in the high-AAR group (29.94% vs 21.71%, p0.001). The levels of C-reactive protein, erythrocyte sedimentation rate, white blood cell count, bilirubin, fibrinogen, thrombin time, D-dimer, and brain natriuretic peptide were also significantly higher in the low-AAR group compared with the high-AAR group. The levels of albumin and IgG were significantly lower in the low-AAR group compared with those of the high-AAR group. The proportion of typical KD cases in the low-AAR group was significantly higher than that in the high-AAR group. Low-AAR correlated with the risk of coronary artery damage and IVIG resistance. Conclusion. Children with KD who had low-AAR value were more likely to develop coronary artery damage and IVIG resistance. Low AAR is a risk factor for CAL, CAA, and IVIG resistance in KD.
机译：客观的。为了研究天冬氨酸氨基转移酶（AST）/丙氨酸氨基转移酶（AST）比（AST / ALT比率，AAR）和静脉内免疫球蛋白（IVIG）抗性，冠状动脉病变（CAL）和冠状动脉动脉瘤（CAA）中的抗冠状动脉动脉瘤（CAA）之间的关联随着川崎病（KD）。设计。我们回顾性地研究了2678名kd的儿童，并将它们分成两组：低AAR组和高AAR组，中位数为1.13作为截止点。在两组之间比较了实验室数据，临床表现和冠状动脉损伤率的差异。结果。低AAR组的Cal的发病率高于疾病发作后2和3-4周的高AAR组（分别为3-4周）。低AAR组的抗性率明显高于高AAR组（29.94％vs 21.71％，P <0.001）。与高AAR组相比，低AAR组在低AAR组中，C反应蛋白，红细胞沉积率，白细胞计数，胆红素，纤维蛋白原，血小板时间，D-二聚体和脑利钠肽的水平也显着较高。与高AAR组相比，低AAR组白蛋白和IgG的水平显着降低。低AAR组典型KD病例的比例显着高于高AAR组。低AAR与冠状动脉损伤的风险和IVIG抗性相关。结论。 KD的儿童具有低AAR值的可能性更容易发生冠状动脉损伤和IVIG抗性。低AAR是CAL，CAA和KD IVIG电阻的危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号