The ubiquitin-proteasome system in glioma cell cycle control

Panagiotis J Vlachostergios; Ioannis A Voutsadakis; Christos N Papandreou

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The ubiquitin-proteasome system in glioma cell cycle control

机译：胶瘤细胞周期控制中的泛素 - 蛋白酶体系

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A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, essential for the consistent recycling of a plethora of proteins with distinct structural and functional roles within the cell, including cell cycle regulation. High grade tumors, such as glioblastomas have an inherent potential of escaping cell cycle control mechanisms and are often refractory to conventional treatment. Here, we review the association of UPS with several UPS-targeted proteins and pathways involved in regulation of the cell cycle in malignant gliomas, and discuss the potential role of UPS inhibitors in reinstitution of cell cycle control.

机译：细胞命运的主要决定因素是细胞周期的调节。在各种肿瘤的发展和进展过程中，这种过程的紧张调节丢失。泛素 - 蛋白酶体系（UPS）构成了通用蛋白质降解途径，其对于一致的蛋白质的一致再循环是必不可少的，所述蛋白质在细胞内具有不同的结构和功能作用，包括细胞周期调节。高级肿瘤，例如胶质母细胞瘤具有逃逸细胞周期控制机制的固有潜力，并且通常对常规治疗具有难治性。在这里，我们审查了具有几种靶向蛋白质和途径的UPS联合，所述蛋白质和途径涉及恶性胶质瘤中细胞周期的调节，并讨论UPS抑制剂在恢复细胞周期控制中的潜在作用。

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《Cell Division》 |2012年第1期|共页
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Panagiotis J Vlachostergios; Ioannis A Voutsadakis; Christos N Papandreou;
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1. Ehd3, a regulator of vesicular trafficking, is silenced in gliomas and functions as a tumor suppressor by controlling cell cycle arrest and apoptosis. [J] . Sahiti Chukkapalli, Mohamed Amessou, Hafedh Dekhil, Carcinogenesis . 2014,第4期

机译：Ehd3，水泡运输的调节剂，在神经胶质瘤中沉默，并通过控制细胞周期停滞和凋亡而起肿瘤抑制作用。
2. A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast. [J] . Yu X, Robinson JF, Sidhu JS, Toxicological sciences: An official journal of the Society of Toxicology . 2010,第2期

机译：基因表达的基于系统的比较揭示了小鼠胚胎成纤维细胞中的镉和甲基汞暴露后，氧化应激的改变，泛素-蛋白酶体系统的破坏以及细胞周期调控的改变。
3. A System-Based Comparison of Gene Expression Reveals Alterations in Oxidative Stress, Disruption of Ubiquitin-Proteasome System and Altered Cell Cycle Regulation after Exposure to Cadmium and Methylmercury in Mouse Embryonic Fibroblast [J] . Xiaozhong Yu Joshua F. Robinson Jaspreet S. Sidhu2 Sungwoo Hong and Elaine M. Faustman1 Toxicological Sciences . 2010,第2期

机译：小鼠胚胎成纤维细胞暴露于镉和甲基汞后，基因表达的基于系统的比较揭示了氧化应激的变化，泛素-蛋白酶体系统的破坏和细胞周期调控的改变。
4. Arsenic trioxide induces both apoptosis and autophagy through stimulation of ER stress and inhibition of ubiquitin-proteasome system in human sarcoma cells [C] . H.-W. Chiu, Y.-C. Tseng, Y.-J. Wang International Congress on Arsenic in the Environment . 2014

机译：通过刺激人类肉瘤细胞中的ER应激和泛素 - 蛋白酶体系的ER应激和抑制来诱导细胞凋亡和自噬
5. Polymorphisms in candidate genes in the ubiquitin-proteasome system and Parkinson's disease: A case-control genetic association study controlling for population structure. [D] . Hutter, Carolyn Mary. 2008

机译：泛素-蛋白酶体系统中候选基因的多态性与帕金森氏病：一项控制种群结构的病例对照遗传协会研究。
6. The ubiquitin-proteasome system in glioma cell cycle control [O] . Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Christos N Papandreou 2012

机译：胶质瘤细胞周期控制中的泛素-蛋白酶体系统
7. The ubiquitin-proteasome system in glioma cell cycle control. [O] . Vlachostergios, P.J., Voutsadakis, I.A., Papandreou, C.N. 2012

机译：胶质瘤细胞周期控制中的泛素-蛋白酶体系统。

The ubiquitin-proteasome system in glioma cell cycle control

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