Multi-Dimensional High-Performance Liquid Chromatographic Determination of Chiral Amino Acids and Related Compounds in Real World Samples

Chiharu ISHII; Aogu FURUSHO; Chin-Ling HSIEH; Kenji HAMASE

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Multi-Dimensional High-Performance Liquid Chromatographic Determination of Chiral Amino Acids and Related Compounds in Real World Samples

机译：多维高效液相色谱法测定现实世界样本中的手性氨基酸和相关化合物

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Chiral amino acid analysis, especially the determination of trace levels of D-enantiomers, is currently gathering attention in a variety of research areas including the food/clinical sciences. These D-amino acids had long been believed to be absent in the higher animals. However, by the advances of analytical technologies, some of the D-enantiomers are found in mammals including humans and increasingly recognized as novel physiologically-active substances and/or biomarkers. For the determination of these D-amino acids and related compounds in real world samples, utilization of sensitive and selective methods is essential and multi-dimensional HPLC is one of the straightforward approaches. In the present review, two/three-dimensional HPLC methods and biological/medical applications focusing on our current studies are summarized.

机译：手性氨基酸分析，特别是测定痕量的D-对映体，目前在包括食品/临床科学的各种研究领域的各种研究领域采取关注。这些D-氨基酸长期以来，在高等动物中不存在。然而，通过分析技术的进步，一些D-映体在包括人类的哺乳动物中发现，并且越来越被认为是新的生理活性物质和/或生物标志物。为了测定现实世界样本中这些D-氨基酸和相关化合物，利用敏感和选择性方法是必需的，多维HPLC是直接方法之一。在本综述中，总结了两个/三维HPLC方法和重点关注我们目前研究的生物/医疗应用。

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《CHROMATOGRAPHY》 |2020年第1期|共17页
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Chiharu ISHII; Aogu FURUSHO; Chin-Ling HSIEH; Kenji HAMASE;
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Chiral separationMulti-dimensional HPLCAmino acidsHydroxy acids;

机译：手性分离多维HPLCamino atchydroxy酸;

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专利

1. High-Performance Liquid Chromatographic Determination of Chiral Amino Acids Using Pre-Column Derivatization with o-Phthalaldehyde and N-tert-Butyloxycarbonyl-D-cysteine and Application to Vinegar Samples [J] . Aogu FURUSHO, Mintranee OBROMSUK, Takeyuki AKITA, CHROMATOGRAPHY . 2020,第3期

机译：使用柱子衍生化与 -phthalaldehyde的高效液相色谱法测定手性氨基酸和 N - Tert - 丁氧基羰基-D-半胱氨酸并应用于醋样品

2. Reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-mexiletine prepared by microwave irradiation with four new chiral derivatizing reagents based on trichloro-s-triazine having amino acids as chiral auxiliaries and 10 others having amino acid amides [J] . Bhushan R., Dixit S. Journal of chromatography, A: Including electrophoresis and other separation methods . 2010,第49期

机译：反相高效液相色谱分离（R，S）-美西汀的非对映异构体，方法是用四种基于三氯-s-三嗪的新型手性衍生试剂进行微波辐照，微波衍生有三种手性衍生试剂，其中三氯-s-三嗪具有氨基酸作为手性助剂，其余十种具有氨基酸酰胺

3. Enantioselective Determination of Extraterrestrial Amino Acids Using a Two-Dimensional Chiral High-Performance Liquid Chromatographic System [J] . Kenji HAMASE, Yusuke NAKAUCHI, Yurika MIYOSHI, CHROMATOGRAPHY . 2014,第2期

机译：二维手性高效液相色谱系统对映体测定地外氨基酸

4. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ENANTIOSEPARATION OF β-AMINO ACIDS [C] . Antal Peter, R. Berkecz, I.. Ilisz the European Peptide Symposium . 2007

机译：β-氨基酸的高性能液相色谱映射分析

5. Detection of amino acids and their enantiomeric ratios in various samples, and the development of a new stationary phase for the chiral separation of amino acids. [D] . Kullman, John Peter. 2000

机译：检测各种样品中的氨基酸及其对映体比率，并开发用于氨基酸手性分离的新固定相。

6. Determination of Optical Purity of Lactic Acid-Based Chiral Liquid Crystals and Corresponding Building Blocks by Chiral High-Performance Liquid Chromatography and Supercritical Fluid Chromatography [O] . Anna Poryvai, Terezia Vojtylová-Jurkovičová, Michal Šmahel, 2019

机译：手性高效液相色谱和超临界流体色谱法测定乳酸基手性液晶及其相应结构单元的光学纯度

7. Multi-Dimensional High-Performance Liquid Chromatographic Determination of Chiral Amino Acids and Related Compounds in Real World Samples [O] . Chiharu ISHII, Aogu FURUSHO, Chin-Ling HSIEH, 2020

机译：多维高效液相色谱法测定现实世界样本中的手性氨基酸和相关化合物

8. Determination of (alpha)-dialkylamino acids and their Enantiomers in Geological Samples by High-Performance Liquid Chromatography after Dervatization with a Chiral Adduct of (omicron)-Phthaldialdehyde [R] . Zhoa, M. , Bada, J. L. 1995

机译：用（） - 萘二甲醛手性加合物衍生化后高效液相色谱法测定地质样品中的α-二烷基氨基酸及其对映体

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2. 高效液相色谱手性固定相的研究Ⅴ——二肽叔丁酰胺型手性固定相拆分α-氨基酸、二茂铁基氨基酸及二肽衍生物对映异构体 [J] . 刘晋钫 ,徐修容 ,黄嘉鑫 . 色谱 . 1990,第004期

3. 手性衍生化-HPLC法测定达托霉素中8种手性氨基酸的D,L-构型 [J] . 刘浩 ,裘亚 . 中国抗生素杂志 . 2016,第001期

4. 高效液相色谱法测定变压器油中糠醛及相关呋喃类化合物 [J] . 徐燕锋 . 上海计量测试 . 2012,第001期

5. 高效液相色谱手性固定相的研究Ⅲ.L-氨基酸-叔丁酰胺型固定相的制备及α-氨基酸衍生物和α-氨基-烃基膦酸酯对映体的拆分 [J] . 唐琴梅 ,徐修容 ,施铭英 . 色谱 . 1989,第003期

6. 高效液相色谱法测定甲基化氨基酸及其相关化合物 [C] . 刘要武 . 第二届全国生物分析化学学术研讨会 . 1994

7. 含特特拉姆酸酯结构天然产物不对称合成中相关化合物的手性高效液相色谱分析 [A] . 孔俊琼 . 2008

1. 一种超高效液相色谱-串联四级杆质谱检测动物体液或组织样本中氨基酸的方法 [P] . 中国专利： CN109633030A . 2019-04-16

2. 一种基于超高压高效液相色谱串联质谱法测定土壤中的5种硝基酚类化合物的方法 [P] . 中国专利： CN111965287A . 2020-11-20

3. method for the simultaneous determination of purine derivatives and pirimidine, amino acid n - acetylated and dicarbossilici acids in a biological sample by high-performance liquid chromatography (hplc) and high-performance on kit. [P] . 外国专利： ITRM20050085A1 . 2006-09-01

机译：高效液相色谱法（hplc）和高性能试剂盒同时测定生物样品中嘌呤衍生物和嘧啶，氨基酸正乙酰化和二碳碳硅酸的方法

4. Crown Ether Chiral Stationary Phase and Chiral Column for the Liquid Chromatographic Resolution of Biologically Active Racemic Primary Amino Compounds [P] . 外国专利： KR100364255B1 . 2002-12-12

机译：冠醚手性固定相和手性色谱柱用于生物活性外消旋伯氨基化合物的液相色谱拆分

5. Crown Ether Chiral Stationary Phase and Chiral Column for the Liquid Chromatographic Resolution of Biologically Active Racemic Primary Amino Compounds [P] . 外国专利： KR20020020440A . 2002-03-15

机译：冠醚手性固定相和手性色谱柱用于生物活性外消旋伯氨基化合物的液相色谱拆分

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Multi-Dimensional High-Performance Liquid Chromatographic Determination of Chiral Amino Acids and Related Compounds in Real World Samples

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