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首页> 外文期刊>Circulation journal >Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease
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Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease

机译：与心房颤动的肌球蛋白轻链4（MyL4）中的RS4968309在没有结构心脏病的心房颤动患者的导管消融后预测临床结果

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Background: Atrial fibrillation (AF) is the most common arrhythmia with serious complications and a high rate of recurrence after catheter ablation. Recently, mutation of MYL4 was reported as responsible for familial atrial cardiomyopathy and AF. This study aimed to determine the association between polymorphism in MYL4 with the onset and recurrence of AF. Methods?and?Results: A total of 7 single-nucleotide polymorphisms were selected by linkage disequilibrium and genotyped in 510 consecutive AF patients and 192 controls without structural heart disease. A total of 246 AF patients who underwent cryoballoon ablation had a 1-year scheduled follow-up study for AF recurrence. C allele and CC genotype of rs4968309 and A allele of rs1515751were associated with AF onset both before and after adjustment of covariation (age, sex, hypertension, and diabetes). AF type and left atrial size were different among the genotypes of rs4968309. Moreover, CC genotype of rs4968309 increased susceptibly of AF recurrence after cryoballoon ablation. The prevalence of hypertension was associated with rs1515752, and left atrial size was associated with the genotype of rs2071438. Conclusions: C allele and CC genotype of rs4968309 in MYL4 were associated with AF onset and recurrence. Moreover, the A allele of rs1515751 had a significant association with AF onset. The polymorphisms of MYL4 can predict AF onset and prognosis after ablation in AF patients without structural heart disease.
机译：背景：心房颤动（AF）是最常见的心律失常，具有严重并发症和导管消融后的高复发率。最近，据报道，MyL4的突变为家庭心房心肌病和AF。该研究旨在确定MyL4多态性与AF的发作和复发的关联。方法？结果：通过键入不平衡和510个连续AF患者和192例对照选择，共选出7种单核苷酸多态性，并在没有结构性心脏病的情况下进行基因分型。共有246名接受冷冻消融的AF患者有一个1年的AF复发预定的后续研究。 C RS4968309的C等位基因和CC基因型和与AF发作的rs1515751的等位基因在调整协变（年龄，性别，高血压和糖尿病）之前和之后。 AF型和左心房尺寸在RS4968309的基因型中不同。此外，在冷冻气球消融后，CC基因型敏感地增加了AF复发。高血压的患病率与RS1515752相关，左心房大小与RS2071438的基因型相关。结论：CRS4968309中的C等位基因和CC基因型与AF发作和复发相关。此外，RS1515751的等位基因与AF发作有很大关系。 MyL4的多态性可以预测AF在没有结构心脏病的AF患者中消融后的发病和预后。

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