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首页> 外文期刊>Circulation journal >Fasting and Non-Fasting Triglycerides and Risk of Cardiovascular Events in Diabetic Patients Under Statin Therapy
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Fasting and Non-Fasting Triglycerides and Risk of Cardiovascular Events in Diabetic Patients Under Statin Therapy

机译：禁食和非禁食甘油三酯和糖尿病患者患者的心血管事件风险

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Background: Few data specifically investigate associations between fasting/non-fasting triglycerides (TG) and cardiovascular (CV) events under statin therapy among Japanese diabetic patients. Methods?and?Results: We recruited 4,988 participants with diabetes from the EMPATHY study. Median follow-up was 3 years. We evaluated associations between serum fasting/non-fasting TG and first CV events in Cox-regression hazard models adjusted by classical risk factors. CV events were defined as (1) major adverse cardiac events (MACE) including myocardial infarction, stroke, or cardiac death; and (2) CV diseases (CVD) including myocardial infarction, unstable angina, ischemic stroke, or large artery disease or peripheral arterial disease. Fasting as well as non-fasting TG were associated with MACE (adjusted hazard ratio [HR]: 1.017 per 10 mg/dL; 95% confidence interval [CI]: 1.000–1.037; P=0.046, adjusted HR: 1.028 per 10 mg/dL; 95% CI: 1.006–1.050; P=0.0091) and CVD (adjusted HR: 1.024 per 10 mg/dL; 95% CI: 1.011–1.038; P=4.4×10sup?3/sup, adjusted HR: 1.028 per 10 mg/dL; 95% CI: 1.010–1.046; P=4.9×10sup?3/sup). Comparing the top quartile with the bottom quartile of non-fasting TG, adjusted HR significantly increased 5.18 (95% CI: 1.38–18.3, P=0.014) for MACE, and 2.40 (95% CI: 1.11–4.75, P=0.021) for CVD, while adjusted HR did not change when divided into quartile of fasting TG. Conclusions: Non-fasting TG could be considered as a substitute for fasting TG as a risk stratification for future CV events among Japanese diabetic patients.
机译：背景：少数数据专门研究日语糖尿病患者的禁食/非禁食甘油三酯（TG）和心血管（CV）事件之间的关联。方法？结果：我们招募了4,988名参与者与同理心研究的糖尿病。中位后续时间为3年。我们评估了通过经典风险因素调整的Cox-返回危险模型中血清禁食/非禁食TG和第一CV事件之间的关联。 CV事件被定义为（1）主要不良心脏事件（立柱），包括心肌梗死，中风或心脏死亡; （2）CV疾病（CVD），包括心肌梗死，不稳定的心绞痛，缺血性卒中或大动脉疾病或外周动脉疾病。禁食以及非禁食TG与芯片有关（调整后的危险比[HR]：1.017每10 mg / dL; 95％置信区间[CI]：1.000-1.037; P = 0.046，调整为每10毫克：1.028 / DL; 95％CI：1.006-1.050; p = 0.0091）和CVD（调节的HR：每10 mg / dl; 95％CI：1.011-1.038; P = 4.4×10 ？3 ，调整后的HR：每10 mg / dL 1.028; 95％CI：1.010-1.046; p = 4.9×10 ？3 ）。将顶部四分位与非禁食TG的底部四分位数进行比较，调整后的HR显着增加5.18（95％CI：1.38-18.3，P = 0.014），2.40（95％CI：1.11-4.75，P = 0.021）对于CVD，当调整后的HR除以禁食TG的四分位数时没有改变。结论：非禁食TG可被视为禁食TG作为日本糖尿病患者未来CV事件的风险分层的替代品。

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