Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report

Sangeeta Mutnuri; Hania Kassem; John Badalamenti; You-Wen Qian; Christopher Marquez; Marjan Afrouzian

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Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report

机译：淋巴瘤相关的单克隆干酪肾上腺素肾盂肾炎及与丙型肝炎病毒感染的关系：案例报告

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We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Our case raises awareness regarding possibility of monoclonality in the renal biopsy of HCV-infected patients and exemplifies the crucial role the renal biopsy plays in detecting lymphoid malignancies where clinical features are ambiguous.

机译：我们在患有急性肾功能衰竭的慢性丙型肝炎患者中举报了I型Cryoglobuliny肾小球肾炎的情况。由于对免疫荧光显微镜的意外单克隆kappa限制，肾活检揭示了膜中血血管蛋白酶血症，提出了造血性造血性恶性肿瘤的意外单克隆κ血症。骨髓活检揭示了边缘区淋巴瘤的存在。我们的案例提高了对HCV感染患者肾活检中单蛋白酶体的可能性的认识，并举例说明肾活组织检查在检测淋巴恶性肿瘤中的关键作用，其中临床特征含糊不清。

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《Case Reports in Nephrology》 |2019年第6期|共5页
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Sangeeta Mutnuri; Hania Kassem; John Badalamenti; You-Wen Qian; Christopher Marquez; Marjan Afrouzian;
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1. Treatment of hepatitis C virus infection in patients with mixed cryoglobulinemic syndrome and cryoglobulinemic glomerulonephritis [J] . Rutledge Stephanie M., Chung Raymond T., Sise Meghan E. Hemodialysis international . 2018,第Suppla1期

机译：混合冷冻纤维素综合征患者丙型肝炎病毒感染和冷冻纤维素肾小球肾炎的治疗方法
2. CRYOGLOBULINEMIC GLOMERULONEPHRITIS IN A PATIENT WITH HEPATITIS B VIRUS INFECTION AND B-CELL LYMPHOMA [J] . American Journal of Kidney Diseases: The official journal of the National Kidney Foundation . 2020,第4期

机译：具有乙型肝炎病毒感染和B细胞淋巴瘤的患者中的肾上腺激素肾小球肾炎
3. Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report [J] . Michiko Shimada, Norio Nakamura, Tetsu Endo, BMC Nephrology . 2017,第1期

机译：基于Daclatasvir / Asunaprevir的直接作用抗病毒治疗改善丙型肝炎病毒相关的干胆管素血上膜血管肾炎：案例报告
4. 6.5 The epidemiology of hepatitis E virus and the relationship between infection in pigs and humans in a community of agricultural-food system in Nan, Thailand [C] . Soawapak Hinjoy Annual conference of the International Society of Exposure Science . 2014

机译：6.5在泰国楠府的一个农业食品系统社区中，戊型肝炎病毒的流行病学以及猪和人之间的感染关系
5. The epidemiology of hepatitis E virus and the relationship between infection in pigs and humans in a community of agricultural-food system in Nan Province, Thailand [D] . Hinjoy, Soawapak. 2012

机译：泰国南部省农业食品系统社区中戊型肝炎病毒的流行病学以及猪与人之间的感染关系
6. Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report [O] . Sangeeta Mutnuri, Hania Kassem, John Badalamenti, 2019

机译：淋巴瘤相关的低温球蛋白肾小球肾炎及其与丙型肝炎病毒感染的关系：病例报告。
7. Clinicopathological study of mixed cryoglobulinemic glomerulonephritis secondary to Hepatitis B virus infection [O] . CHAO LI, HANG LI, WEI SU, 2020

机译：混合冷冻纤维素肾小球肾炎继发于乙型肝炎病毒感染的临床病理学研究
8. Recommendations for Postexposure Interventions to Prevent Infection with Hepatitis B Virus, Hepatitis C Virus, or Human Immunodeficiency Virus, and Tetanus in Persons Wounded During Bombings and Similar Mass-Casualty Events-United States, 2008: Recommendations of the Centers for Disease Control (CDC). Morbidity and Mortality Weekly Report, Recommendation and Reports, Vol.57, No. RR-6 [R] . 2008

机译：关于暴露后干预以防止乙型肝炎病毒，丙型肝炎病毒或人类免疫缺陷病毒感染的建议，以及在爆炸和类似的大规模伤亡事件中受伤人员的破伤风 - 美国，2008年：疾病控制中心（CDC）的建议。发病率和死亡率每周报告，建议和报告，第57卷，第RR-6号

Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report

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