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首页> 外文期刊>Clinical Interventions in Aging >Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis
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Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis

机译：IL-6和HSCRP血清水平对IV溶栓患者功能预后的影响：回顾性分析

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Purpose: We evaluated the relationship between pretreatment IL-6 and hsCRP levels, symptom severity and functional outcome of patients with acute ischemic stroke (AIS) treated with IV-thrombolysis. Patients and Methods: IL-6 and hsCRP samples were obtained from 83 consecutively treated Caucasian patients with AIS prior to initiation of IV-thrombolysis. Severity of stroke symptoms was assessed using the National Institutes of Health Stroke Scale (NIHSS), whereas functional outcome was assessed with modified Rankin Scale (mRS). The commercially available sets of enzymatic immune tests were used to estimate the concentrations of inflammatory markers in serum. Results: Medians of IL-6 serum concentrations prior to IV-thrombolysis were lower in patients with favorable (mRS 0– 2 pts) functional outcome than in those with unfavorable (mRS 3– 6 pts) functional outcome, both at hospital dismission (5.92: 2.30– 7.71 vs 9.46: 3.79– 17.29 pg/mL; p 0.01) and on the ninetieth day from stroke onset (5.87: 2.30– 10.58 vs 10.9: 5.94– 17.28 pg/mL; p 0.01). There were no existing differences regarding hsCRP levels between groups (2.49: 0.11– 9.82 vs 4.44: 0.32– 9.87 mg/dL; p =0.30 and 2.57: 0.11– 2.57 vs 2.83: 0.32– 9.32 mg/dL; p =0.75, respectively). Patients with lacunar strokes were characterized by lower median of IL-6 (5.96: 2.87– 13.0% vs 7.29: 2.30– 17.28; p = 0.02) and hsCRP (2.25: 0.11– 9.82 vs 4.84: 0.35– 9.87; p =0.01) than those with nonlacunar infarctions. Multivariate analysis showed an impact of IL-6 on mRS measured on hospital dismission and after three months, regardless of their initial NIHSS, presence of hemorrhagic transformation and type 2 diabetes. No impact of hsCRP, lacunar etiology and patients’ age on functional outcome existed. Conclusion: Regardless of the stroke etiology, pretreatment of IL-6, but not of hsCRP levels, may help to predict functional outcome after IV-thrombolysis independently of symptom severity and stroke complications.
机译：目的：通过IV溶栓治疗的急性缺血性卒中（AIS）的预处理IL-6和HSCRP水平，症状严重程度和功能结果评估了与IV溶栓治疗的患者的关系。患者和方法：在引发IV溶栓之前，从83名连续治疗的白种人患者获得IL-6和HSCRP样品。利用国家卫生冲程量表（NIHSS）评估卒中症状的严重程度，而使用改进的Rankin规模（MRS）评估了功能结果。市售的酶免疫试验组用于估算血清中炎症标志物的浓度。结果：IV-6血清血清血清浓度的中位数在患者（0-2分）的患者中较低，而不是在医院裂缝中的不利（3-6分）功能结果的患者（5.92 ：2.30- 7.71 vs 9.46：3.79-17.29 pg / ml; p <0.01）和卒中发作的硫氮日（5.87：2.30-10.58与10.9：5.94-17.28 pg / ml; p <0.01）。对组之间的HSCRP水平没有存在的差异（2.49：0.11-9.82 Vs 4.44：0.32-9.87mg / dL; P = 0.30和2.57：0.11- 2.57 Vs 2.83：0.32-9.32mg / dl; p = 0.75 ）。患者的患者的患者的IL-6中位数较低（5.96：2.87-13.0％VS 7.29：2.30-17.28; P = <0.02）和HSCRP（2.25：0.11-9.82 VS 4.84：0.35-9.87; P = 0.01 ）而不是那些非丑陋令的人。多变量分析显示IL-6对在医院脱盐的MRS上的影响，无论其初始NIHS，出血转化的存在和2型糖尿病。没有对功能结果存在的HSCRP，Levunar病因和患者年龄的影响。结论：无论卒中病因如何，IL-6的预处理，但不具有HSCRP水平，可能有助于在IV溶栓后独立于症状严重程度和中风并发症预测功能结果。

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