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首页> 外文期刊>Clinical ophthalmology >Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse environment challenge in subjects with a history of dry eye and ocular allergy
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Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse environment challenge in subjects with a history of dry eye and ocular allergy

机译：通过对眼睛和眼镜历史的受试者控制的不利环境挑战加剧了过敏性结膜炎的症状和症状

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Background: The goal of this study was to assess the effect of a controlled adverse environment (CAE) challenge on subjects with both allergic conjunctivitis and dry eye.Methods: Thirty-three subjects were screened and 17 completed this institutional review board-approved study. Subjects underwent baseline ocular assessments and conjunctival allergen challenge (CAC) on days 0 and 3. Those who met the ocular redness and itching criteria were randomized to receive either the controlled adverse environment (CAE) challenge (group A, n = 9) or no challenge (group B, n = 8) at day 6. Thirty minutes after CAE/no-CAE, subjects were challenged with allergen and their signs and symptoms graded. Exploratory confocal microscopy was carried out in a subset of subjects at hourly intervals for 5 hours post-CAC on days 3 and 6.Results: Seven minutes post-CAC, subjects exposed to the CAE had significantly greater itching (difference between groups, 0.55 ± 0.25, P = 0.028), conjunctival redness (0.59 ± 0.19, P = 0.002), episcleral redness (0.56 ± 0.19, P = 0.003) and mean overall redness (mean of conjunctival, episcleral, and ciliary redness, 0.59 ± 0.14, P < 0.001). The mean score at 7, 15, and 20 minutes post-CAC for conjunctival redness (0.43 ± 0.17, P = 0.012), episcleral redness (0.49 ± 0.15, P = 0.001), mean overall redness in all regions (0.43 ± 0.15, P = 0.005), and mean chemosis (0.20 ± 0.08, P = 0.017) were also all significantly greater in CAE-treated subjects. Confocal microscopic images of conjunctival vessels after CAC showed more inflammation in CAE-treated subjects.Conclusion: In subjects with both dry eye and allergic conjunctivitis, exposure to adverse environmental conditions causes an ocular surface perturbation that can intensify allergic reactions.
机译：背景：本研究的目标是评估受控不利环境（CAE）对具有过敏性结膜炎和干眼症的受试者的攻击的影响。筛选了三十三名科目，17个完成了该机构审查委员会批准的研究。受试者接受基线眼科评估和结膜过敏原挑战（CAC）的日子0和3.符合眼发红和瘙痒标准的人被随机化以接受受控不利环境（CAE）挑战（A组，N = 9）或没有挑战（B组，N = 8）在第6天。CAE / NO-CAE后30分钟，受试者用过敏原挑战，其迹象和症状分级。探索性共聚焦显微镜在每小时在CAC后的每小时间隔中进行5小时的副间隔3和6.结果：第7分钟后，暴露于CAE的受试者瘙痒明显升高（组之间的差异，0.55± 0.25，p = 0.028），结膜发红（0.59±0.19，p = 0.002），外卡发红（0.56±0.19，p = 0.003）和平均发红（结膜，外循环和睫状发红，0.59±0.14，p <0.001）。 CAC后7,15和20分钟的平均分数用于结膜发红（0.43±0.17，p = 0.012），外卡发红（0.49±0.15，p = 0.001），所有地区的整体发红（0.43±0.15， P = 0.005），CAE处理受试者中的平均化学过滤（0.20±0.08，p = 0.017）也明显更大。 CAC后结膜血管的共聚焦显微图像在CAC处理后的炎症中显示出更多的炎症。结论：在具有干眼症和过敏性结膜炎的受试者中，暴露于不利的环境条件导致可能加剧过敏反应的眼部扰动。

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