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首页> 外文期刊>Acute and critical care. >Comparison of the efficacy of an infusion pump or standard IV push injection to deliver naloxone in treatment of opioid toxicity
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Comparison of the efficacy of an infusion pump or standard IV push injection to deliver naloxone in treatment of opioid toxicity

机译：输液泵或标准IV推注递送纳洛酮治疗阿片类毒性的疗效比较

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BACKGROUND:The optimal goal of naloxone infusion in intensive care units is to ameliorate opioid-induced side effects in therapy or eliminate the symptoms of opioid toxicity in overdoses. Accurately monitoring and regulating the doses is critical to prevent adverse effects related to naloxone administration. The present study aimed to compare treatment outcomes when using two methods of intravenous naloxone infusion: an infusion pump or the standard method.METHODS:This study involved 80 patients with signs and symptoms of opioid overdose. The patients were randomly assigned into two groups with respect to intravenous infusion of naloxone by either an infusion pump or the standard method.RESULTS:Comparison of study parameters between the two groups at 12 and 24 hours after intervention showed significantly more compensatory acid-base imbalance in the naloxone infusion pump group. In the group that received naloxone by pump, only one patient experienced withdrawal symptoms, but withdrawal symptoms appeared in 12 patients (30.0%) in the standard intravenous infusion group within 12 hours and in seven additional patients (17.5%) within 24 hours of intervention. In the group receiving pump-based naloxone infusion therapy, no another complications were reported; however in the standard infusion group, the 12-hour and 24-hour complication rates were 55.0% and 32.5%, respectively. The length of hospital stay was 2.85±1.05 and 4.22±0.92 days for the pump and standard infusion groups, respectively (P0.001).CONCLUSIONS:Naloxone infusion using an infusion pump may be safer with regard to hemodynamic stability, resulting in shorter hospitalization periods, and fewer posttreatment complications.
机译：背景：在重症监护单位中纳洛酮输注的最佳目标是改善阿片类药物诱导的治疗副作用或消除产量过量的阿片类毒性的症状。准确监测和调节剂量对于防止与纳洛酮施用相关的不良反应至关重要。本研究旨在比较使用两种静脉内纳洛酮输注的方法：输液泵或标准方法。方法：本研究涉及80例患有阿片类药物过量的症状和症状。通过输注泵或标准方法随机将患者随机分为两组，分为两组纳洛酮或标准方法。结果：干预后12和24小时的两组之间的研究参数比较显示出明显更多的补偿性酸碱的不平衡在纳洛酮输注泵组中。在通过泵接受纳洛酮的组中，只有一种患者经历了戒断症状，​​但在12小时内，在24小时内，在标准静脉注射组中出现了12名患者（30.0％）的戒断症状（17.5％）在干预后24小时内。在接受基于泵的纳洛酮输注治疗的基团中，没有报道另一个并发症;然而，在标准输注组中，12小时和24小时并发症率分别为55.0％和32.5％。泵和标准输液组的住院时间长度为2.85±1.05和4.22±0.92天（P <0.001）。结论：使用输液泵的纳洛酮输注可能更安全，关于血流动力学稳定性，导致住院时间较短期间，较少的后处理并发症。

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