• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical toxicology: the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists >Comparison of lower-dose versus higher-dose intravenous naloxone on time to recurrence of opioid toxicity in the emergency department
【24h】

Comparison of lower-dose versus higher-dose intravenous naloxone on time to recurrence of opioid toxicity in the emergency department

机译：低剂量与高剂量静脉内纳洛酮对急诊部中阿片类毒性复发的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: The initial dose of naloxone administered to patients who present to the emergency department (ED) with opioid overdose is highly variable. The objective of this study was to determine if the initial dose of intravenous (IV) naloxone given to these patients was associated with the time to recurrence of opioid toxicity. Methods: This was a multicenter retrospective cohort study, conducted at two academic EDs in the United States. Consecutive adults who had a positive response to naloxone for opioid overdose in the ED were included. Patients were categorized into two groups based on initial IV naloxone dose administered: 0.4 mg (lower-dose) or 1-2 mg (higher-dose). The main outcome measure was the time to recurrence of opioid toxicity requiring a second dose of naloxone. Secondary outcomes included the need for naloxone continuous infusion and adverse events. Results: The study included 84 patients with 42 patients receiving lower-dose and 42 patients receiving higher-dose naloxone. Median time to re-dose of naloxone was similar between the lower-dose (72 [IQR 46-139] minutes) and higher-dose (70 [IQR 44-126] minutes) groups (p=.810). There were 12 patients (29%) in the lower-dose group and 17 patients (41%) in the higher-dose group who subsequently required continuous infusions (p=.359). The proportion of patients with adverse events was similar between lower-dose and higher-dose groups (31% versus 41%, p=.495). There was no difference in the incidence of specific withdrawal related adverse effects. Conclusions: The initial dose of naloxone given to patients in the ED does not influence the time to recurrence of opioid toxicity.
机译：介绍：向呈递阿片类药物过量的患者给予急诊部（ED）的患者的初始剂量是高度可变的。本研究的目的是确定对这些患者的静脉内（IV）纳洛酮的初始剂量是否与阿片类毒性复发的时间相关。方法：这是一项多中心回顾性队列研究，在美国的两个学术署进行。包括在ED中对纳洛酮进行阳性反应的连续成年人。患者基于初始IV纳洛酮剂量施用：0.4mg（低剂量）或1-2mg（高剂量）。主要结果措施是需要进行第二剂纳洛酮的阿片类毒性复发的时间。二次结果包括需要纳洛酮的连续输注和不良事件。结果：该研究包括84例患者接受较低剂量的42例患者和接受高剂量纳洛酮的42名患者。在低剂量（72 [IQR 46-139]分钟）和更高剂量（70 [IQR 44-126]分钟）基团（P = .810）之间相似的中间剂量的纳洛酮的时间相似。在较低剂量组中有12名患者（29％）和17名患者（41％），随后需要连续输注（P = .359）。低剂量和高剂量基团（31％对41％，P = .495）之间相似的患者的比例相似。特定戒断相关不良反应的发生率没有差异。结论：对ED中患者的纳洛酮的初始剂量不会影响阿片类药物毒性的复发时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号