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Mussel-Inspired Cell/Tissue-Adhesive, Hemostatic Hydrogels for Tissue Engineering Applications

机译：贻贝启发的细胞/组织粘合剂，用于组织工程应用的止血水凝胶

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The combination of multiple physiological (swelling, porosity, mechanical, and biodegradation) and biological (cell/tissue-adhesive, cell proliferation, and hemostatic) properties on a single hydrogel has great potential for skin tissue engineering. Adhesive hydrogels based on polydopamine (PDA) have become the most popular in the biomedical field; however, integrating multiple properties on a single adhesive hydrogel remains a challenge. Here, inspired by the chemistry of mussels, we developed PDA–sodium alginate–polyacrylamide (PDA–SA–PAM)-based hydrogels with multiple physiological and biological properties for skin tissue engineering applications. The hydrogels were prepared by alkali-induced polymerization of DA followed by complexation with SA in PAM networks. The chemical composition of the hydrogels was characterized by X-ray photoelectron spectroscopy. PDA–SA complexed chains were homogeneously dispersed in the PAM network and exhibited good elasticity and excellent mechanical properties, such as a compressive stress of 0.24 MPa at a compression strain of 70% for 0.4PDA–SA–PAM. The adhesive hydrogel also maintained a highly interconnected porous structure (～94% porosity) along with PDA microfibrils. The hydrogel possesses outstanding swelling and biodegradability properties. Owing to the presence of the PDA–SA complex in the PAM network, the hydrogels show good adhesion to various substrates (plastic, skin, glass, computer screens, and leaves); for example, the adhesive strength of the 0.4PDA–SA–PAM to porcine skin was 24.5 kPa. The adhesive component of the PDA–SA chains in the PAM network significantly improves the cell proliferation, cell attachment, cell spreading, and functional expression of human skin fibroblasts (CCD-986sk) and keratinocytes. Moreover, the PDA chains exhibited good hemostatic properties, resulting in rapid blood coagulation. Considering their excellent cell affinity, and rapid blood coagulation ability, these mussel-inspired hydrogels have substantial potential for skin tissue engineering applications.
机译：单个水凝胶上的多种生理（膨胀，孔隙，机械和生物降解）和生物（细胞/组织粘合剂，细胞增殖和止血）性能的组合具有很大的皮肤组织工程潜力。基于聚二胺（PDA）的粘合水凝胶已成为生物医学领域最受欢迎的水凝胶;然而，在单个粘合剂水凝胶上整合多种性质仍然是一个挑战。这里，受贻贝化学的启发，我们开发了具有多种生理和生物学性能的PDA-藻酸钠 - 聚丙烯酰胺（PDA-SA-PAM）的水凝胶，用于皮肤组织工程应用。通过碱诱导的DA聚合制备水凝胶，然后用SA在PAM网络中络合。通过X射线光电子体光谱表征水凝胶的化学成分。 PDA-SA复合链均匀地分散在PAM网络中，并且表现出良好的弹性和优异的机械性能，例如0.24MPa的压缩应力为0.4pda-sa-pam。粘合水凝胶还与PDA微纤维保持高度互连的多孔结构（〜94％孔隙率）。水凝胶具有出色的溶胀和生物降解性。由于PAM网络中PDA-SA复合物存在，水凝胶对各种基板（塑料，皮肤，玻璃，计算机屏幕和叶子）显示出良好的粘附性;例如，0.4pda-sa-pam至猪皮的粘合强度为24.5kpa。 PAM网络中PDA-SA链的粘合剂组分显着改善了人体皮细胞（CCD-986SK）和角质形成细胞的细胞增殖，细胞附着，细胞扩散和功能表达。此外，PDA链表现出良好的止血性能，导致血液凝固快速。考虑到其优异的细胞亲和力，以及快速的血液凝固能力，这些贻贝风格的水凝胶具有显着的皮肤组织工程应用潜力。

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