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首页> 外文期刊>ACS Omega >Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
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Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow

机译：连续流动快速合成三苯基磷矿的开发和扩展

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A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. In addition, the reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. In addition, scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert -butylphenyl) phosphite was achieved in 88% yield.
机译：一种新的用于合成三苯基亚磷酸酯及其衍生物的方法，以连续流动开发。对于20 s的总停留时间，在微反应器中制备靶产物，与标准单批次反应条件相比，反应时间显着缩短。此外，各种底物的反应在优化条件下良好地使相应的产物良好。反应物可以以化学计量的比例使用，使反应更有效，经济，环保。此外，设计和组装了缩放装置，并且在88％的产率下，实现了三千克规模的产生（高达18.4kg / h）的Tris（2,4-二 -

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