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首页> 外文期刊>ACS Omega >Real-Time Intraoperative Pressure Monitoring to Avoid Surgically Induced Localized Brain Injury Using a Miniaturized Piezoresistive Pressure Sensor
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Real-Time Intraoperative Pressure Monitoring to Avoid Surgically Induced Localized Brain Injury Using a Miniaturized Piezoresistive Pressure Sensor

机译：实时术中压力监测，避免使用小型化压阻式压力传感器避免手术诱导的局部脑损伤

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Neurosurgical procedures often cause damage to the brain tissue at the periphery from surgical manipulations. Especially during retraction, a large amount of pressure could be applied on the brain surface, which can damage it, leading to brain herniation, which can be fatal for patients. To resolve this issue, we have developed a pressure sensor that can be used to monitor the applied pressure during surgery for intraoperative care. This device was tested on a rodent model to create a superficial surgically induced damage profile for three different applied pressures (30, 50, and 70 mmHg) and compared to a standard intracranial pressure monitoring system. Magnetic resonance imaging has been performed after surgical procedures to detect the herniation caused by applied pressure. To evaluate the damage to brain cells and tissue rupture, histological analysis was performed using hematoxylin and eosin staining. A scoring system was developed to understand the severity of the surgically induced brain injury, which will help neurosurgeons to limit the pressure to an optimum point without causing damage.
机译：神经外科手术经常导致外科手术的外围脑组织损伤。特别是在缩回过程中，可以在脑表面上施加大量的压力，这可能会损坏它，导致脑疝，这对于患者来说可能是致命的。为了解决这个问题，我们开发了一种压力传感器，可用于监测术中护理手术期间的施加压力。在啮齿动物模型上测试该装置，以形成浅表外科诱导的损伤轮廓，用于三种不同的施加的压力（30,50和70mmHg），并与标准的颅内压力监测系统进行比较。磁共振成像已经在手术手术后进行，以检测由施加压力引起的疝气。为了评估对脑细胞和组织破裂的损伤，使用苏木精和曙红染色进行组织学分析。开发了评分系统以了解手术诱导的脑损伤的严重程度，这将有助于神经外部，以将压力限制为最佳点而不会导致损坏。

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