• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>ACS Omega >Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride–Captisol Inclusion Complexes
【24h】

Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride–Captisol Inclusion Complexes

机译：物理化学表征，分子对接和胶质脂素 - Captisol包装复合物的体外溶解

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride–Captisol complex showed an A_(L)-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride–Captisol complex was higher in distilled water of pH ～6.0 than in phosphate buffer of pH 7.2.
机译：本研究研究了CAPTISOL一种化学改性环糊精的效果对胶林植物的体外溶解。我们通过物理混合或冷冻干燥技术制备了不同质量比（1：1,1：2和1：3 W / W）的GlimePiride-Captisol复合物，并发现与Capisol的络合增强了胶质脂素的水溶性。分子对接和动态模拟预测复杂形成;同时，傅里叶变换红外光谱，差分扫描量热法，粉末X射线衍射法，扫描电子显微镜表明了支持络合的分子相互作用。我们还发现包含复合物优于一种物理混合物，以提高胶质脂醇与Capisol和增强水溶性的粘合性。胶质脂素 - Captisol复合物的相溶解度研究显示A_（L）型型材，暗示形成1：1包合物的形成。该研究还揭示了pH影响了复合物的稳定性，因为在pH〜6.0的蒸馏水中的蒸馏水稳定性常数比pH7.2的磷酸盐缓冲液更高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号